Protection from lethal influenza virus challenge by oral type 1 interferon
Protection from lethal influenza virus challenge by oral type 1 interferon
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DOI：
10.1016/j.bbrc.2007.02.019
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发表时间：
2007-04-13
影响因子：
3.1
通讯作者：
Bennett, Alayne L.
中科院分区：
文献类型：
--
作者：
Beilharz, Manfred W.;Cummins, Joseph M.;Bennett, Alayne L.
高致病性禽流感在野生鸟类种群中持续存在，使人们对采取控制措施限制可能的人间大流行产生了兴趣。因此，我们在小鼠模型中研究了低剂量口服ifn - α作为抗流感感染的潜在治疗方法的有效性。我们已经确定了一种最佳的低口服剂量ifn - α，当每天给药作为预防性治疗时，可以保护C57BL/6J小鼠免受小鼠适应的人流感病毒a /PR/8/34 （H1N1）的致命攻击。这些结果为低剂量1型干扰素预处理在人流感控制中的应用提供了强有力的支持。(c) 2007爱思唯尔公司版权所有。
The persistence of highly pathogenic avian influenza within wild bird populations has forged interest in control measures to limit a possible human pandemic. We therefore investigated the efficacy of low dose oral administration of IFN-alpha as a potential therapy against influenza infection in a murine model. We have identified an optimal low oral dose of IFN-alpha that when delivered daily as prophylactic therapy protects C57BL/6J mice from a lethal challenge with mouse adapted human influenza virus A/PR/8/34 (H1N1). These results provide strong support for the application of low dose type 1 IFN pretreatment to human influenza control. (c) 2007 Elsevier Inc. All rights reserved.