Exponential diagnostic signal amplification via dendritic chain reaction: the dendritic effect of a self-immolative amplifier component
Exponential diagnostic signal amplification via dendritic chain reaction: the dendritic effect of a self-immolative amplifier component
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DOI：
10.1039/c1nj20486f
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发表时间：
2012-01-01
影响因子：
3.3
通讯作者：
Shabat, Doron
中科院分区：
文献类型：
--
作者：
Karton-Lifshin, Naama;Shabat, Doron
信号放大技术通常用于增强诊断信号。我们最近开发了一种通过独特的树突链反应获得指数信号放大的新方法。本文报道了自焚树突放大器元件对信号放大效果的评价。四个末端单位数量不同的树突通过自焚分解途径产生指数信号放大的能力进行了评估。由3个末端单元组成的第一代平台树突在水环境下具有良好的拆卸速率和稳定性。这项研究证明了基于树突结构的分子的效率。
Signal amplification techniques are commonly used to boost diagnostic signals. We have recently developed a new approach for exponential signal amplification obtained through a distinctive dendritic chain reaction. Here we report evaluation of the effect of the self-immolative dendritic amplifier component on the signal amplification. Four dendrons with various numbers of end-units were evaluated for the ability to produce exponential signal amplification through self-immolative disassembly pathways. The dendron composed of a first-generation platform with three end-units exhibited the best characteristics with rapid disassembly rate and good stability under aqueous conditions. This study demonstrates the efficiency of molecules based on dendritic structures.