Extracellular vesicles in parasitic diseases.
Extracellular vesicles in parasitic diseases.
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DOI：
10.3402/jev.v3.25040
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发表时间：
2014
影响因子：
16
通讯作者：
Del Portillo HA
中科院分区：
文献类型：
--
作者：
Marcilla A;Martin-Jaular L;Trelis M;de Menezes-Neto A;Osuna A;Bernal D;Fernandez-Becerra C;Almeida IC;Del Portillo HA
寄生虫病影响数十亿人，被认为是一个重大的公共卫生问题。据估计，有近400种物种寄生在人类身上，其中约90种造成了巨大的临床负担和死亡率。不幸的是，它们在很大程度上被忽视，因为它们主要是贫穷地区的地方病。与此相关的审查，有越来越多的证据表明，释放的细胞外囊泡（EV）在寄生虫病，寄生虫-寄生虫相互通信以及寄生虫-宿主相互作用。EV参与病原体的传播，并在调节宿主免疫系统中发挥作用。已经针对许多寄生虫感染描述了从寄生虫或寄生细胞产生EV。在这篇综述中，我们提供了EV参与细胞间通讯，调节免疫反应，参与病理学以及它们作为一些主要人类寄生虫病原体的新诊断工具和治疗剂的潜力的最相关的发现。
Parasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality rates. Unfortunately, they are largely neglected as they are mainly endemic to poor regions. Of relevance to this review, there is accumulating evidence of the release of extracellular vesicles (EVs) in parasitic diseases, acting both in parasite–parasite inter-communication as well as in parasite–host interactions. EVs participate in the dissemination of the pathogen and play a role in the regulation of the host immune systems. Production of EVs from parasites or parasitized cells has been described for a number of parasitic infections. In this review, we provide the most relevant findings of the involvement of EVs in intercellular communication, modulation of immune responses, involvement in pathology, and their potential as new diagnostic tools and therapeutic agents in some of the major human parasitic pathogens.