Engineering photoluminescent and magnetic lamellar hydroxyapatite by facile one-step Se/Gd dual-doping.
Engineering photoluminescent and magnetic lamellar hydroxyapatite by facile one-step Se/Gd dual-doping.
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DOI：
10.1039/c8tb00658j
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发表时间：
2018-05
期刊：
影响因子：
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通讯作者：
Honglin Luo;Jing Xie;Lingling Xiong;Zhiwei Yang;G. Zuo;Hongying Wang;Yong Zhu;Y. Wan
中科院分区：
文献类型：
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作者：
Honglin Luo;Jing Xie;Lingling Xiong;Zhiwei Yang;G. Zuo;Hongying Wang;Yong Zhu;Y. Wan
多功能羟基磷灰石（HAp）纳米粒子的设计与合成对于拓展其临床应用具有重要意义。本文报道了一种新型的硒钆双掺杂层状羟基磷灰石（L-HAp-Se-Gd）的合成方法。结果表明，制备的L-HAp-Se-Gd纳米粒子与裸L-HAp相比，在形貌、尺寸和结晶度等方面都发生了明显的变化。XRD结果表明，高掺杂量的Se和Gd降低了HAp薄膜的有序度。结果表明，L-HAp-Se-Gd纳米粒子在紫外光照射下表现出与Gd含量相关的蓝色荧光和磁性。小鼠胚胎成骨细胞（MC 3 T3-E1）的细胞试验表明，由于Se掺入，它们的生物相容性比裸L-HAp有所改善。这些结果表明，L-HAp-Se-Gd纳米颗粒在许多应用中具有潜力，例如多功能基因递送和生物成像。
The design and synthesis of multifunctional hydroxyapatite (HAp) nanoparticles are important in expanding their clinical applications. Herein we report a novel selenium (Se) and gadolinium (Gd) dual-doped lamellar hydroxyapatite (L-HAp-Se-Gd) produced by facile one-step template-assisted synthesis. The results show that the as-prepared L-HAp-Se-Gd nanoparticles exhibit obvious changes in morphology, dimensions, and crystallinity as compared to bare L-HAp. XRD results reveal that high dopant levels of Se and Gd reduce the degree of ordering of HAp lamellae. It is found that the L-HAp-Se-Gd nanoparticles display Gd content-dependent blue fluorescence under ultraviolet (UV) irradiation and magnetic properties. Cell tests with mouse embryo osteoblast cells (MC3T3-E1) reveal their improved biocompatibility over bare L-HAp due to Se incorporation. These results indicate that L-HAp-Se-Gd nanoparticles have potential in numerous applications such as multifunctional gene delivery and bioimaging.