Association of ABO blood groups with the severity of coronary artery disease: a cross-sectional study
Association of ABO blood groups with the severity of coronary artery disease: a cross-sectional study
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DOI：
10.11909/j.issn.1671-5411.2019.09.005
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发表时间：
2019-01-01
影响因子：
2.5
通讯作者：
Zhang, Wen-Bin
中科院分区：
文献类型：
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作者：
Hong, Xu-Lin;Li, Ya;Zhang, Wen-Bin
目的探讨ABO血型与冠状动脉疾病（CAD）严重程度是否相关。方法 2015年1月至2017年12月，纳入1425例经选择性冠状动脉造影确诊的初诊CAD患者纳入横断面研究，收集其基线特征、ABO血型、Gensini评分。进行多元线性回归分析来测试 CAD 严重程度和 ABO 血型之间的关联。结果 A 型血组的 Gensini 评分显着高于非 A 型血组（41.2 +/- 32 比 38 +/- 27；P = 0.026）。调整年龄、男性、吸烟、CAD家族史、高血压、糖尿病和高胆固醇血症后，多元线性回归表明A型血与CAD的严重程度相关（β = 3.298，95% CI：0.91-6.505，P = 0.044）。在糖尿病组中，调整年龄、男性、CAD家族史、高胆固醇血症、吸烟和高血压后，A型血也与Gensini评分增加相关（P = 0.02）。结论 这项横断面研究的数据表明，A 型血是中国人群和中国 2 型糖尿病患者 CAD 严重程度的独立危险因素。
Objective To investigate whether ABO blood groups is associated with the severity of coronary artery disease (CAD). Methods Between January 2015 and December 2017, 1425 first diagnosed CAD patients confirmed by selective coronary angiography were recruited into this cross-sectional study, and their baseline characteristics, ABO blood groups, Gensini score were collected. Multiple linear regression analysis was performed to test the association between the severity of CAD and ABO blood groups. Results The Gensini score was significantly higher in the blood group A than in the non-A groups (41.2 +/- 32 vs. 38 +/- 27; P = 0.026). After adjusting for age, male, smoking, family history of CAD, hypertension, diabetes mellitus and hypercholesterolemia, multivariate linear regression indicated that blood group A was associated with the severity of CAD (beta = 3.298, 95% CI: 0.91-6.505, P = 0.044). In diabetes group, A blood type was also associated with increased Gensini score (P = 0.02) after adjusting for age, male, family history of CAD, hypercholesterolemia, smoking and hypertension. Conclusion In this cross-sectional study, the data indicated that blood group A was an independent risk factor of severity of CAD in Chinese population and Chinese patients with type 2 diabetes.