The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces
The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces
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DOI：
10.1242/jcs.183699
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发表时间：
2016-03-15
影响因子：
4
通讯作者：
Assoian, Richard K.
中科院分区：
文献类型：
--
作者：
Mui, Keeley L.;Chen, Christopher S.;Assoian, Richard K.
钙粘蛋白和整合素通过肌动蛋白细胞骨架内在地连接并且共享共同的信号分子。尽管整合素-肌动蛋白轴的机械感应作用早已被人们所认识，但越来越多的文献表明钙粘蛋白也对机械力产生响应。越来越多的证据表明，机械驱动的整合素和钙粘蛋白之间的串扰调节这些受体的空间分布，它们的信号中间体，肌动蛋白细胞骨架和细胞内的力量。整合素和钙粘蛋白之间的这种相互作用可以控制纤连蛋白基质组装和信号传导，并且粘着斑处的牵引力和粘着连接处的细胞间张力之间的精细平衡对于定向集体细胞迁移至关重要。在这篇评论中，我们讨论了两个中心思想：（1）整合素和钙粘蛋白之间的动态相互作用如何调节细胞内信号和细胞外基质的空间组织，以及（2）正在形成的共识，即细胞内力是决定细胞行为的中心机制，指导组织发育并最终驱动生理学。
Cadherins and integrins are intrinsically linked through the actin cytoskeleton and share common signaling molecules. Although mechanosensing by the integrin-actin axis has long been appreciated, a growing body of literature now demonstrates that cadherins also transduce and respond to mechanical forces. Mounting evidence shows that mechanically driven crosstalk between integrins and cadherins regulates the spatial distribution of these receptors, their signaling intermediates, the actin cytoskeleton and intracellular forces. This interplay between integrins and cadherins can control fibronectin matrix assembly and signaling, and a fine balance between traction forces at focal adhesions and intercellular tension at adherens junctions is crucial for directional collective cell migration. In this Commentary, we discuss two central ideas: (1) how the dynamic interplay between integrins and cadherins regulates the spatial organization of intracellular signals and the extracellular matrix, and (2) the emerging consensus that intracellular force is a central mechanism that dictates cell behavior, guides tissue development and ultimately drives physiology.