Patterns of regional brain activation associated with different forms of motor learning
Patterns of regional brain activation associated with different forms of motor learning
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DOI：
10.1016/s0006-8993(00)02365-9
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发表时间：
2000-07-14
期刊：
影响因子：
2.9
通讯作者：
Eidelberg, D
中科院分区：
文献类型：
--
作者：
Ghilardi, MF;Ghez, C;Eidelberg, D
为了研究区域脑血流量的变化，在执行和学习达到的动作，我们采用了一个家庭的运动学和动态控制的运动任务中，认知，记忆和执行功能的性能进行了区分和定量的特点。在O-15标记的水正电子发射断层扫描（PET）过程中，12名右撇子受试者在数字化平板电脑上移动他们的优势手：从中心位置到等距目标，在计算机屏幕上用光标与音调同步显示。在前一周，所有受试者练习三个运动任务：1）运动到一个可预测的目标序列; 2）学习新的视觉转换，其中屏幕光标运动旋转30度-60度; 3）通过试错法学习新的目标序列，通过使用先前获得的例程在任务中对空间工作记忆施加沉重的负担。控制条件是观察屏幕和音频显示。使用统计参数映射分析减影图像以识别显著的脑激活灶。可预测序列的执行的特点是运动时间和空间误差适度减少。潜在的激活模式涉及初级运动和感觉区、小脑、基底神经节。对旋转参照系的适应是程序性学习的一种形式，与施加的方向偏差的减少有关。这项任务与右后顶叶皮层的激活有关。新的序列是明确学习的。在背外侧前额叶和前扣带皮层发现了显着的激活。在这项研究中，我们介绍了一系列灵活的运动任务具有相似的运动学特征和不同的空间属性。这些任务可用于评估运动学习的特定方面，并在健康和疾病中进行成像。(C)2000 Elsevier Science B. V.保留所有权利。
To examine the variations in regional cerebral blood flow during execution and learning of reaching movements, we employed a family of kinematically and dynamically controlled motor tasks in which cognitive, mnemonic and executive features of performance were differentiated and characterized quantitatively. During O-15-labeled water positron emission tomography (PET) scans, twelve right-handed subjects moved their dominant hand on a digitizing tablet:From a central location to equidistant targets displayed with a cursor on a computer screen in synchrony with a tone. In the preceding week, all subjects practiced three motor tasks: 1) movements to a predictable sequence of targets; 2) learning of new visuomotor transformations in which screen cursor motion was rotated by 30 degrees-60 degrees; 3) learning new target sequences by trial and error, by using previously acquired routines in a task placing heavy load on spatial working memory. The control condition was observing screen and audio displays. Subtraction images were analyzed with Statistical Parametric Mapping to identify significant brain activation foci. Execution of predictable sequences was characterized by a modest decrease in movement time and spatial error. The underlying pattern of activation involved primary motor and sensory areas, cerebellum, basal ganglia. Adaptation to a rotated reference frame, a form of procedural learning, was associated with decrease in the imposed directional bias. This task was associated with activation in the right posterior parietal cortex. New sequences were learned explicitly. Significant activation was found in dorsolateral prefrontal and anterior cingulate cortices. In this study, we have introduced a series of flexible motor tasks with similar kinematic characteristics and different spatial attributes. These tasks can be used to assess specific aspects of motor learning with imaging in health and disease. (C) 2000 Elsevier Science B.V. All rights reserved.