Heart transplantation in baboons using 1,3-galactosyl transferase gene-knockout pigs as donors: initial experience
Heart transplantation in baboons using 1,3-galactosyl transferase gene-knockout pigs as donors: initial experience
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DOI：
10.1038/nm1171
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发表时间：
2005-01-01
期刊：
影响因子：
82.9
通讯作者：
Cooper, DKC
中科院分区：
文献类型：
--
作者：
Kuwaki, K;Tseng, YL;Cooper, DKC
Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-alpha1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies.
