Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks.
Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks.
复制标题
非甾体类抗炎药：心血管风险的概述。
DOI：
10.3390/ph3072146
复制
发表时间：
2010-07-07
期刊：
影响因子：
--
通讯作者：
E Vonkeman H
中科院分区：
文献类型：
--
作者：
Meek IL;Van de Laar MA;E Vonkeman H
虽然阿司匹林可能提供保护，但其他非阿司匹林非类固醇抗炎药(NSAIDs)可能会导致严重的心血管副作用和并发症。这导致了非类固醇抗炎药的心血管不良事件的一般“黑匣子”警告。该综述探讨了阿司匹林保护作用的不同机制，非甾体抗炎药引起的高血压、水肿和心力衰竭的肾血管效应，引起心肌梗死和中风的心血管效应，以及非类固醇抗炎药和阿司匹林之间可能的有害相互作用。
While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general "black box" warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causing hypertension, edema and heart failure, the cardiovascular effects causing myocardial infarction and stroke, and the possible deleterious interaction between NSAIDs and aspirin.