Evidence for pineal involvement in timing implantation in the western spotted skunk.
Evidence for pineal involvement in timing implantation in the western spotted skunk.
复制标题
松果体参与西部斑点臭鼬植入时间的证据。
DOI：
10.1111/j.1600-079x.1986.tb00720.x
复制
发表时间：
1986
影响因子：
10.3
通讯作者：
Mead,RA
中科院分区：
文献类型：
--
作者：
May,R;Mead,RA
实验的目的是检验这一假设，即松果体介导的影响，改变白天的长度，从而植入人口内的斑点臭鼬。对完整的、假上级颈神经节切除（SCGx）、SCGx和SCGx/双侧眼眶摘除（BI）妊娠臭鼬进行自然光周期，并监测着床前期的持续时间。在第二组实验中，通过两种方法将褪黑激素给予怀孕的臭鼬，以确定这种松果体激素是否会模仿短日照或B 1对植入前期持续时间的影响。双侧SCGx（可能使松果体失神经支配）对植入前期的平均持续时间没有影响（232 ± 57 vs. 199 ± 6天）。然而，SCGx逆转了B1对着床的抑制作用，因为SCGx/B1动物的着床前期平均持续时间与完整对照组无显著差异（262 ± 46 vs. 214 ± 11天），但与去核动物相比显著缩短（262 ± 46 vs. 316 ± 45天）。对于每天下午注射褪黑激素或接受褪黑激素硅橡胶胶囊植入的动物，褪黑激素显着延长了植入前期的持续时间。这些结果与西方斑点臭鼬中松果体光周期诱导胚泡着床的假设一致。
Experiments were designed to test the hypothesis that the pineal gland mediates the effects of changing day length and thereby synchronizes implantation within the population of spotted skunks. Intact, sham‐superior cervical ganglionectomized (SCGx), SCGx, and SCGx/bilateral orbitally enucleated (BI) pregnant skunks were subjected to a natural photoperiod, and the duration of the preimplantation period was monitored. In a second set of experiments, melatonin was administered to pregnant skunks via two methods to determine whether or not this pineal hormone would mimic the effects of short day photoperiods or B 1 on duration of the preimplantation period. Bilateral SCGx, which presumably denervated the pineal, had no effect on the average duration of the preimplantation period (232 ± 57 vs. 199 ± 6 days). However, SCGx reversed the inhibitory effect of B1 on implantation as SCGx/B1 animals had an average duration of the preimplantation period that was not significantly different from intact controls (262 ± 46 vs. 214 ± 11 days) but was significantly shortened in comparison to enucleated animals (262 ± 46 vs. 316 ± 45 days). Melatonin significantly lengthened the duration of the preimplantation period in animals receiving either daily afternoon injections of melatonin or those receiving melatonin Silastic capsule implants. These results are consistent with the hypothesis that the pineal gland synchronizes photoperiod‐induced blastocyst implantation in the western spotted skunk.