CHANGES IN ISLET BLOOD-FLOW IN RATS WITH NIDDM
CHANGES IN ISLET BLOOD-FLOW IN RATS WITH NIDDM
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DOI：
10.1007/s001250050163
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发表时间：
1994-07-01
期刊：
影响因子：
8.2
通讯作者：
PENICAUD, L
中科院分区：
文献类型：
--
作者：
ATEF, N;PORTHA, B;PENICAUD, L
采用非放射性微球技术，对GK系和NIDDM新生大鼠注射STZ（nO-STZ）后的胰岛血流量进行定量。在基础状态下，血浆胰岛素水平和胰岛血流量之间存在良好的相关性，即与对照组大鼠相比，GK和nO-STZ大鼠的血浆胰岛素水平和胰岛血流量分别增加或减少。GK大鼠胰岛血流量和血浆胰岛素水平的增加被双侧小脑下迷走神经切断术消除。在葡萄糖挑战期间，对照大鼠的血浆胰岛素和胰岛血流量增加了一倍，而糖尿病大鼠的这些参数没有改变。这些数据表明，在葡萄糖挑战过程中，糖尿病大鼠的胰岛血流发生了变化，这可能参与了先前在这两种模型中描述的异常葡萄糖诱导的胰岛素分泌。
Islet blood flow was quantified in NIDDM rats either of the GK strain on after neonatal injection of STZ (nO-STZ), using the non-radioactive microsphere technique. In the basal state, there was a good correlation between plasma insulin level and islet blood flow, i.e. both were increased or decreased in comparison to those of control rats in GK and nO-STZ rats, respectively. The increased islet blood flow and plasma insulin levels observed in the GK rats were abolished by bilateral subdiaphragmatic vagotomy. During a glucose challenge, whereas plasma insulin and islet blood flow were doubled in control rats, these parameters were not modified in the diabetic rats. These data demonstrate an alteration in the islet blood flow of diabetic rats during a glucose challenge which could participate in the abnormal glucose-induced insulin secretion previously described in these two models.