Nivolumab-induced organizing pneumonia in a melanoma patient.
Nivolumab-induced organizing pneumonia in a melanoma patient.
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黑色素瘤患者中纳武利尤单抗诱导的机化性肺炎。
DOI：
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发表时间：
2016
影响因子：
2.4
通讯作者：
R. Okuyama
中科院分区：
文献类型：
--
作者：
T. Sano;H. Uhara;Y. Mikoshiba;A. Kobayashi;R. Uchiyama;K. Tateishi;Hiroshi Yamamoto;R. Okuyama
我们报告的情况下，一个70岁的妇女与阴道黑色素瘤和多个转移在肺部。在第三次纳武利尤单抗给药后，尽管没有呼吸道症状，但在听诊时出现了室内空气静息动脉血氧饱和度降低伴双侧基底细爆裂音。计算机断层扫描显示磨玻璃样阴影伴气隙实变，以特殊的分布散在分布，大多数在肺内现有转移性肿瘤周围观察到。从纳武利尤单抗末次给药后第42天至第56天，她接受了地塞米松1-2 mg/体，用于预防脑转移立体定向放射治疗后的不良事件。在纳武利尤单抗最后一次给药后3个月，计算机断层扫描显示肺炎改善，肺部转移性病灶的大小和数量减少，尽管一些病灶显示扩大。Nivo治疗后肺炎模式与临床效果之间的关系需要进一步研究。
We report the case of a 70-year-old woman with vaginal melanoma and multiple metastases in the lung. After the third dose of nivolumab, decreased room-air resting arterial oxygen saturation with bilateral basal fine crackles on auscultation developed despite the absence of respiratory symptoms. Computed tomography showed ground-glass opacities with airspace consolidations scattered with a peculiar distribution, and most were observed around the existing metastatic tumors in the lung. From the 42nd day to the 56th day after the last administration of nivolumab, she received dexamethasone 1-2 mg/body for the prevention of adverse events after stereotactic radiation for brain metastasis. At 3 months after the last administration of nivolumab, a computed tomography scan revealed improvement of the pneumonia and a decreased size and number of metastatic lesions in the lung, although some lesions showed enlargement. Further examination is needed to clarify the relationship between the pattern of pneumonia after Nivo therapy and clinical effects.
DOI：
10.1056/nejmoa1200690
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Topalian SL;Hodi FS;Brahmer JR;Gettinger SN;Smith DC;McDermott DF;Powderly JD;Carvajal RD;Sosman JA;Atkins MB;Leming PD;Spigel DR;Antonia SJ;Horn L;Drake CG;Pardoll DM;Chen L;Sharfman WH;Anders RA;Taube JM;McMiller TL;Xu H;Korman AJ;Jure-Kunkel M;Agrawal S;McDonald D;Kollia GD;Gupta A;Wigginton JM;Sznol M
通讯作者：
Sznol M