Clinical evaluation of the lysis-centrifugation blood culture system for the detection of fungemia and comparison with a conventional biphasic broth blood culture system
Clinical evaluation of the lysis-centrifugation blood culture system for the detection of fungemia and comparison with a conventional biphasic broth blood culture system
复制标题
裂解离心血培养系统检测真菌血症的临床评价以及与传统双相肉汤血培养系统的比较
DOI：
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发表时间：
1984
影响因子：
9.4
通讯作者：
G. Roberts
中科院分区：
文献类型：
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作者：
J. Billé;R. Edson;G. Roberts
在一项比较真菌血培养研究中，一种裂解-离心系统（Isolator; Du Pont Co., Wilmington, Del.）检测出89%的真菌血症；裂解-离心系统在83%的时间内完全或明显早于双相脑心输液瓶系统检测到真菌血症。裂解-离心系统对热带念珠菌和心念珠菌引起的真菌血症的早期检测特别有用。在53%的具有临床意义的发作中，早期发现直接有助于真菌血症患者的治疗。高量级念珠菌病（大于5 CFU/ml血液）与感染血管内导管的存在以及与白色念珠菌以外的念珠菌种类显著相关。在接受抗真菌药物治疗或移除感染血管内导管的患者监测期间，裂解-离心系统对真菌血症的检测敏感。
In a comparative fungal blood culture study, a lysis-centrifugation system (Isolator; Du Pont Co., Wilmington, Del.) detected 89% of all episodes of fungemia; the lysis-centrifugation system detected fungemia exclusively or significantly earlier than did a biphasic brain heart infusion bottle system 83% of the time. The lysis-centrifugation system was particularly useful in the early detection of fungemia caused by Candida tropicalis and Candida glabrata. In 53% of the clinically significant episodes, the earlier detection was directly helpful in the management of patients with fungemia. High-magnitude candidemia (greater than 5 CFU/ml of blood) was significantly associated with the presence of an infected intravascular catheter and with Candida species other than Candida albicans. The lysis-centrifugation system was sensitive in the detection of fungemia during the monitoring of patients receiving antifungal agents or after removal of an infected intravascular catheter.