Optical coherence tomography detects characteristic retinal nerve fiber layer thickness corresponding to band atrophy of the optic discs
Optical coherence tomography detects characteristic retinal nerve fiber layer thickness corresponding to band atrophy of the optic discs
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DOI：
10.1016/j.ophtha.2004.05.035
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发表时间：
2004-12-01
期刊：
影响因子：
13.7
通讯作者：
Negi, A
中科院分区：
文献类型：
--
作者：
Kanamori, A;Nakamura, M;Negi, A
目的：利用光学相干断层扫描（OCT）分析带萎缩眼视网膜神经纤维层（RNFL）的厚度，评价OCT对RNFL损失特征模式的检测能力。设计：横断面、回顾性研究。对象：对18例视交叉肿瘤压迫所致双颞偏视患者34只眼进行了研究。根据Goldmann验光后的视野损失分级将所有眼睛分为3组。干预措施：用OCT测量视网膜神经纤维层厚度。主要观察指标：用OCT测量视盘周围视网膜神经纤维层厚度（直径3.4 mm圆）。计算OCT参数的变化，包括水平（鼻+颞象限RNFL厚度）和垂直值（上+下象限RNFL厚度）基于160只正常眼睛的数据。3个视野评分组间比较采用方差检验分析。计算水平、垂直值的受试者工作特征（ROC）曲线，并比较曲线下面积（AUC）。结果：带状萎缩眼的视网膜神经纤维层厚度在各OCT参数上均有所下降。RNFL平均厚度和水平值的减少率与视野分级相关。水平值的AUC为0.970+/-0.011，与垂直值的AUC（0.903+/-0.022）差异显著。结论：RNFL厚度减少程度与视野缺损程度相关。光学相干断层扫描能够识别这些眼睛中RNFL丢失的特征模式。眼科2004;美国眼科学会2004。
Objectives: To analyze retinal nerve fiber layer (RNFL) thickness in eyes with band atrophy by use of optical coherence tomography (OCT) and to evaluate the ability of OCT to detect this characteristic pattern of RNFL loss.Design: Cross-sectional, retrospective study.Participants: Thirty-four eyes of 18 patients with bitemporal hemianopia caused by optic chiasm compression by chiasmal tumors were studied. All eyes were divided into 3 groups according to visual field loss grading after Goldmann perimetry.Interventions: Retinal nerve fiber layer thickness measurements with OCT.Main Outcome Measures: Retinal nerve fiber layer thickness around the optic disc was measured by OCT (3.4-mm diameter circle). Calculation of the changes in OCT parameters, including the horizontal (nasal + temporal quadrant RNFL thickness) and vertical values (superior + inferior quadrant RNFL thickness) was based on data from 160 normal eyes. Comparison between the 3 visual field grading groups was done with the analysis of variance test. The receiver operating characteristic (ROC) curve for the horizontal and vertical value were calculated, and the areas under the curve (AUC) were compared.Results: Retinal nerve fiber layer thickness in eyes with band atrophy decreased in all OCT parameters. The reduction rate in average and temporal RNFL thickness and horizontal value was correlated with visual field grading. The AUC of horizontal value was 0.970+/-0.011, which was significantly different from AUC of vertical value (0.903+/-0.022).Conclusions: The degree of RNFL thickness reduction correlated with that of visual field defects. Optical coherence tomography was able to identify the characteristic pattern of RNFL loss in these eyes. Ophthalmology 2004;111:2278-2283 (C) 2004 by the American Academy of Ophthalmology.