Extracellular matrix components in breast cancer progression and metastasis
Extracellular matrix components in breast cancer progression and metastasis
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DOI：
10.1016/j.breast.2013.07.012
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发表时间：
2013-08-01
期刊：
影响因子：
3.9
通讯作者：
Oskarsson, Thordur
中科院分区：
文献类型：
--
作者：
Oskarsson, Thordur
细胞外基质 (ECM) 由调节细胞行为的高度可变和动态的成分组成。 ECM 的蛋白质组成和物理特性通过生化和生物力学机制控制细胞命运。考虑到 ECM 受到干扰可能会产生严重后果并导致癌症等病理状况，因此需要精心策划和彻底的监管。在乳腺癌中，许多 ECM 蛋白显着失调，特定的基质成分促进肿瘤进展和转移扩散。有趣的是，与乳腺癌发展相关的几种 ECM 蛋白与在组织重塑（例如乳腺退化）状态期间诱导的一组 ECM 蛋白基本上重叠。纤维状胶原、纤连蛋白、透明质酸和基质细胞蛋白是退化和癌症常见的基质成分。此外，近年来，其中一些蛋白质已被确定为乳腺癌转移微环境的重要组成部分。此外，特定的 ECM 分子、其受体或酶修饰剂与治疗干预的抵抗力密切相关。对这些 ECM 蛋白和下游 ECM 介导的信号通路的进一步分析可能为识别晚期乳腺癌的药物靶标提供一系列可能性。 (C) 2013 Elsevier Ltd. 保留所有权利。
The extracellular matrix (ECM) is composed of highly variable and dynamic components that regulate cell behavior. The protein composition and physical properties of the ECM govern cell fate through biochemical and biomechanical mechanisms. This requires a carefully orchestrated and thorough regulation considering that a disturbed ECM can have serious consequences and lead to pathological conditions like cancer. In breast cancer, many ECM proteins are significantly deregulated and specific matrix components promote tumor progression and metastatic spread. Intriguingly, several ECM proteins that are associated with breast cancer development, overlap substantially with a group of ECM proteins induced during the state of tissue remodeling such as mammary gland involution. Fibrillar collagens, fibronectin, hyaluronan and matricellular proteins are matrix components that are common to both involution and cancer. Moreover, some of these proteins have in recent years been identified as important constituents of metastatic niches in breast cancer. In addition, specific ECM molecules, their receptors or enzymatic modifiers are significantly involved in resistance to therapeutic intervention. Further analysis of these ECM proteins and the downstream ECM mediated signaling pathways may provide a range of possibilities to identify druggable targets against advanced breast cancer. (C) 2013 Elsevier Ltd. All rights reserved.