Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information
Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information
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DOI：
10.1073/pnas.95.24.14506
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发表时间：
1998-11-24
影响因子：
11.1
通讯作者：
Cahill, L
中科院分区：
文献类型：
--
作者：
Alkire, MT;Haier, RJ;Cahill, L
通过使用局部脑葡萄糖的正电子发射断层扫描来检查两个内侧颞叶结构（海马区和杏仁核）在长期陈述性记忆编码中的参与。对八名健康受试者进行正电子发射断层扫描，受试者被动地聆听一系列重复的不相关单词。 24小时后通过偶然自由回忆测试评估单词记忆，然后自由回忆的单词百分比与编码期间的葡萄糖活性相关。结果显示，左侧海马区（以背侧海马旁回为中心）的活动与单词回忆之间存在显着的相关性（r = 0.91，P < 0.001）。左侧或右侧杏仁核的活动与回忆之间没有发现相关性。这些发现为海马参与长期陈述性记忆编码提供了证据，并为杏仁核不参与非情绪材料的陈述性记忆形成的观点提供了证据。
Participation of two medial temporal lobe structures, the hippocampal region and the amygdala, in long-term declarative memory encoding was examined by using positron emission tomography of regional cerebral glucose. Positron emission tomography scanning was performed in eight healthy subjects listening passively to a repeated sequence of unrelated words. Memory for the words was assessed 24 hr later with an incidental free recall test, The percentage of words freely recalled then was correlated with glucose activity during encoding. The results revealed a striking correlation (r = 0.91, P < 0.001) between activity of the left hippocampal region (centered on the dorsal parahippocampal gyrus) and word recall. No correlation was found between activity of either the left or right amygdala and recall. The findings provide evidence for hippocampal involvement in long-term declarative memory encoding and for the view that the amygdala is not involved,with declarative memory formation for nonemotional material.