Toll-Interacting Protein and Altered Lung Microbiota in Idiopathic Pulmonary Fibrosis.
Toll-Interacting Protein and Altered Lung Microbiota in Idiopathic Pulmonary Fibrosis.
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特发性肺纤维化中的 Toll 相互作用蛋白和改变的肺微生物群。
DOI：
10.1164/rccm.202111-2590le
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发表时间：
2022
影响因子：
24.7
通讯作者：
O'Dwyer,DavidN
中科院分区：
文献类型：
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作者：
Lipinski,JayH;Erb-Downward,JohnR;Huffnagle,GaryB;Flaherty,KevinR;Martinez,FernandoJ;Moore,BethanyB;Dickson,RobertP;Noth,Imre;O'Dwyer,DavidN
特发性肺纤维化（IPF）是一种进行性慢性呼吸道疾病，目前尚无已知的治愈方法，导致全球发病率和死亡率显着升高。临床观察已证明 IPF 患者的肺部微生物群、肺泡炎症、疾病进展和死亡之间存在关联 (1, 2)。 TLR（Toll 样受体）是高度保守的典型先天免疫受体，可识别源自微生物的多种分子模式 (3)。 TLR 信号传导可能调节转基因动物模型中与肺微生物群的相互作用 (4)。 TOLLIP（Toll 相互作用蛋白）是一种复杂蛋白，广泛表达于呼吸道，是 TLR 信号传导的关键调节因子。 TOLLIP 基因的 rs5743890 SNP 与 IPF 死亡率增加相关 (5, 6)。然而，这种 TOLLIP SNP 在调节肺部微生物群中的作用尚不清楚。
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disease of the respiratory tract that has no known cure and results in significant global morbidity and mortality. Clinical observations have demonstrated an association among lung microbiota, alveolar inflammation, disease progression, and death in patients with IPF (1, 2). TLRs (Toll-like receptors) are highly conserved canonical innate immune receptors that recognize a diverse repertoire of molecular patterns derived from microbes (3). TLR signaling may regulate interactions with lung microbiota in transgenic animal models (4). TOLLIP (Toll-interacting protein) is a complex protein, widely expressed in the respiratory tract and a key regulator of TLR signaling. The rs5743890 SNP of the TOLLIP gene is associated with increased mortality in IPF (5, 6). However, the role of this TOLLIP SNP in regulating lung microbiota is unknown.