The viral potassium channel Kcv: structural and functional features
The viral potassium channel Kcv: structural and functional features
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DOI：
10.1016/s0014-5793(03)00777-4
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发表时间：
2003-09-18
期刊：
影响因子：
3.5
通讯作者：
Moroni, A
中科院分区：
文献类型：
--
作者：
Gazzarrini, S;Severino, M;Moroni, A
小球藻病毒PBCV-1是第一个编码功能性钾通道蛋白（Kcv）的病毒。Kcv很小（94 aa），主要由所有已知钾通道孔区典型的M1-P-M2（膜-孔-膜）模块组成。Kcv在三种异源系统中形成功能通道。本文简要介绍了Kcv的门控、通透性和调制特性，并将它们与细菌和哺乳动物的K+通道的特性进行了比较。(C) 2003年欧洲生化学会联合会。Elsevier B.V.版权所有。
The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.