The alpha2 type IX collagen tryptophan polymorphism is associated with the severity of disc degeneration in younger patients with herniated nucleus pulposus of the lumbar spine
The alpha2 type IX collagen tryptophan polymorphism is associated with the severity of disc degeneration in younger patients with herniated nucleus pulposus of the lumbar spine
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DOI：
10.1007/s00264-006-0117-8
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发表时间：
2007-02-01
影响因子：
2.7
通讯作者：
Yasui, N.
中科院分区：
文献类型：
--
作者：
Higashino, K.;Matsui, Y.;Yasui, N.
在芬兰人群中，COL9A2（Trp2）和COL9A3（Trp3）中的色氨酸等位基因与腰椎间盘疾病有关。虽然这些疾病包括各种不同的病理条件，详细的分析，每一个还没有得到很好的记录。本研究的目的是阐明胶原蛋白IX色氨酸等位基因是否影响日本髓核突出患者腰椎间盘的症状性退变。我们对84例接受腰椎间盘切除术的患者进行了前瞻性研究。椎间盘退变的程度通过磁共振图像与胶原IX基因型的关系进行评估。20例患者（21.4%）有Trp2等位基因，没有患者有Trp3等位基因。40岁以下的患者中，Trp2等位基因在手术节段表现出更严重的椎间盘退变比那些没有Trp2等位基因（比值比6.00，P=0.043）。相反，40岁或以上的患者没有表现出椎间盘退变和胶原IX基因型之间的显著相关性。我们的研究结果表明，Trp2等位基因是一个年龄依赖性的危险因素，椎间盘退变的严重程度在年轻患者的症状突出的腰椎髓核。
Tryptophan alleles in COL9A2 (Trp2) and COL9A3 (Trp3) have been linked to lumbar disc diseases in the Finnish population. Although such diseases consist of various pathogenetically different conditions, detailed analysis of each has not been well documented. The aim of this study was to clarify whether the collagen IX tryptophan alleles influence the symptomatic degeneration of the lumbar disc in Japanese patients with herniated nucleus pulposus. We performed a prospective study of 84 patients who underwent lumbar discectomy. The degree of disc degeneration was evaluated by magnetic resonance images in relation to the collagen IX genotype. Twenty patients (21.4%) had the Trp2 allele and no patients had the Trp3 allele. Patients under 40 years with the Trp2 allele showed more severe disc degeneration at the surgical level than did those without the Trp2 allele (odds ratio 6.00, P=0.043). In contrast, patients aged 40 years or over did not show significant association between disc degeneration and collagen IX genotype. Our results suggest that the Trp2 allele is an age-dependent risk factor for the severity of disc degeneration in younger patients with symptomatic herniated nucleus pulposus of the lumbar spine.