Prevalence of xylazine among people who inject drugs seeking medical care at a syringe services program clinic: Miami, Florida, 2023.
Prevalence of xylazine among people who inject drugs seeking medical care at a syringe services program clinic: Miami, Florida, 2023.
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DOI：
10.1016/j.dadr.2023.100209
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发表时间：
2023-12
期刊：
影响因子：
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通讯作者：
Bartholomew, Tyler S
中科院分区：
文献类型：
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作者：
Hauschild, Maia H;Warp, Peyton V;Tookes, Hansel E;Yakir, Ella;Malhotra, Bharat;Malik, Subul;Owens, Cyrus;Suarez, Edward Jr;Serota, David P;Bartholomew, Tyler S
在迈阿密超过一半的样本中发现了赛拉嗪。甲苯噻嗪与伤口就诊相关。迫切需要广泛的甲苯噻嗪测试。我们的目的是报告在美国佛罗里达州迈阿密一家学生经营的免费诊所接受注射毒品（PWID）治疗的人群中赛拉嗪的初步患病率，并确定与赛拉嗪筛查阳性相关的特征。在2023年4月27日至8月17日期间，对在注射器服务计划（SSP）诊所就诊的59例患者进行了回顾性病历审查。我们用快速目视免疫测定条对患者尿样测定了甲苯噻嗪的存在。55.9%（33/59）的尿液样本中存在甲苯噻嗪，包括2份未检出阿片类药物的样本。甲苯噻嗪的存在与无庇护的无家可归者（p = 0.018）、伤口的存在（p = 0.008）、丙型肝炎抗体（p = 0.014）、芬太尼（p = 0.005）和MDMA（p = 0.002）检测阳性显著相关。甲苯噻嗪在美国东南部的高流行率进一步证明了甲苯噻嗪的地理传播和迅速发展的非法药物供应。迫切需要广泛的甲苯噻嗪筛查，以告知注射毒品的人，并研究干预措施，以尽量减少与甲苯噻嗪相关的危害。
Xylazine was found in over half of all samples in Miami. Xylazine was associated with presenting to the clinic with wounds. Widespread xylazine testing is urgently needed. We aimed to report the preliminary xylazine prevalence among people who inject drugs (PWID) treated at a student-run free clinic in Miami, FL, USA and to identify characteristics associated with screening positive for xylazine. A retrospective chart review of 59 patients presenting to a syringe services program (SSP) clinic in was conducted between April 27th and August 17th, 2023. We measured presence of xylazine with rapid visual immunoassay strips on patient urine samples. Xylazine was present in 55.9 % (33/59) of urine samples including 2 without detected opioids. Xylazine presence was significantly associated with unsheltered homelessness (p = 0.018), presence of wound(s) (p = 0.008), and testing positive for hepatitis C antibody (p = 0.014), fentanyl (p = 0.005) and MDMA (p = 0.002). A high prevalence of xylazine in the Southeastern United States furthers evidence of the geographical spread of xylazine and rapidly evolving illicit drug supply. Widespread xylazine screening is urgently needed to inform people who inject drugs and to studyinterventions to minimize harms associated with xylazine.