Accelerating the search for the missing proteins in the human proteome.
Accelerating the search for the missing proteins in the human proteome.
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DOI：
10.1038/ncomms14271
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发表时间：
2017-01-24
影响因子：
16.6
通讯作者：
Ranganathan S
中科院分区：
文献类型：
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作者：
Baker MS;Ahn SB;Mohamedali A;Islam MT;Cantor D;Verhaert PD;Fanayan S;Sharma S;Nice EC;Connor M;Ranganathan S
人类蛋白质组计划（HPP）旨在发现人类基因组编码的所有蛋白质的高严格性数据。目前，人类蛋白质组中约18%的蛋白质（缺失蛋白质）没有高严格性证据（例如质谱法）证实它们的存在，而关于这些缺失蛋白质中的许多蛋白质的更多信息是可用的。在这里，我们将MissingProteinPedia作为社区资源，以加速发现和理解这些缺失的蛋白质。人类蛋白质组计划的目标是对人类基因组编码的120，000种蛋白质进行编目。在这篇综述中，Baker等人专注于缺失的蛋白质，缺乏高严格性蛋白质组学证据的蛋白质，并推出了MissingProteinPedia，一个旨在加速寻找缺失蛋白质的数据库。
The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins. The Human Proteome Project aims to catalogue the ∼20,000 proteins encoded by the human genome. In this review, Baker et al. focus on the missing proteins, proteins that lack high stringency proteomic evidence, and launch MissingProteinPedia, a database aimed at accelerating the search for missing proteins.