Antimicrobial Isopropenyl-dihydrofuranoisoflavones from Crotalaria lachnophora
Antimicrobial Isopropenyl-dihydrofuranoisoflavones from Crotalaria lachnophora
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DOI：
10.1021/np1005218
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发表时间：
2011-02-01
影响因子：
5.1
通讯作者：
Spiteller, Michael
中科院分区：
文献类型：
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作者：
Awouafack, Maurice Ducret;Spiteller, Peter;Spiteller, Michael
沿着8个已知化合物，从豆科药用植物Crotalaria lachnophora中分离得到两个新的具有抗菌活性的异丙烯基二氢呋喃酮。新化合物的结构经1D和2D NMR和高分辨质谱鉴定为7，2 '，4'-三羟基-5“-异丙烯基-4”，5“-二氢呋喃并[2”，3“：5，6]吡喃（1）和4，8-二羟基-2-异丙烯基-2，3-二氢-5H-[1]苯并呋喃并[2，3-B]呋喃并[3，2-g]色烯-5-酮（2）。对CH 2Cl 2/MeOH（1：1）提取物和分离的化合物进行针对一组病原微生物（包括革兰氏阳性和革兰氏阴性细菌和真菌）的体外抗微生物测定。新化合物命名为毛蕊花酮A（1）和B（2），对大肠杆菌和肺炎克雷伯氏菌具有中等抑制活性。
Two new isopropenyl-dihydrofuranoisoflavones exhibiting antimicrobial properties have been isolated along with eight known compounds from the Cameroonian medicinal plant Crotalaria lachnophora. The Structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry as 7,2',4'-trihydroxy-5 ''-isopropenyl-4 '',5 ''-dihydrofurano[2 '',3 '':5,6]isoflavone (1) and 4,8-dihydroxy-2-isopropenyl-2,3-dihydro-5H-[1]benzofuro-[2,3-b]furo[3,2-g] chromen-5-one (2). The CH2Cl2/MeOH (1:1) extract and the compounds isolated were subjected to in vitro antimicrobial assays against a panel of pathogenic Microorganisms, including Gram-Positive and Gram-negative bacteria and fungi. The new compounds, named lachnoisoflavones A (1) and B (2), showed moderate inhibitory activities against Escherichia coli and Klebsielia pneumoniae.