Factors associated with quality of life in middle-aged and older patients living with HIV.
Factors associated with quality of life in middle-aged and older patients living with HIV.
复制标题
DOI：
10.1080/09540121.2016.1146209
复制
发表时间：
2016
期刊：
影响因子：
1.7
通讯作者：
Pereira M
中科院分区：
文献类型：
--
作者：
Monteiro F;Canavarro MC;Pereira M
艾滋病毒感染历来被认为是青年人的疾病;然而，50岁及以上的成年人现在在全世界艾滋病毒病例中所占比例越来越大，包括在葡萄牙。在这种情况下，考虑到与艾滋病毒感染者相关的巨大负担，生活质量（QoL）评估的主题变得越来越重要。本研究的目的是检查与年龄相关的差异，生活质量和抑郁症状的年轻人，中年人和老年人与艾滋病毒，以及社会人口，艾滋病毒相关的和抑郁症状（认知情感和躯体）与生活质量域。样本包括1194艾滋病毒感染者，从10家葡萄牙医院招募。使用WHOQOL-HIV-Bref问卷收集QoL数据。患者还完成了贝克抑郁量表。1194例患者中，185例（15.5%）年龄超过50岁。中年和老年患者在身体、独立性和社会关系领域的生活质量明显较低。关于生活质量的具体方面，中年和老年患者在WHOQOL-HIV-Bref的29个具体方面中的7个方面的得分显著较低，在一个方面（财务资源）的得分较高。总体而言，在中年和老年患者中，较高的教育程度，正在就业，自艾滋病毒诊断以来的时间较短，使用联合抗逆转录病毒治疗和较少的抑郁症状与较高的生活质量评分显着相关。我们的研究结果表明，认知情感和躯体抑郁症状占显着变异的生活质量评分在中年和老年患者。由于健康老龄化的一个重要特征是保持生活质量，这些数据可能提供有用的信息，为定制适合年龄和有效的干预措施，以改善心理健康和生活质量的中年和老年艾滋病毒感染者。
HIV infection has been historically considered a disease of young adults; however, adults aged 50 years and older represent now an increasing proportion of HIV cases worldwide, including in Portugal. In this context, given the considerable burden associated with living with HIV, the topic of quality-of-life (QoL) assessment has become increasingly relevant. The aims of this study were to examine the age-related differences in QoL and depressive symptoms of younger and middle-aged and older adults with HIV as well as the sociodemographic, HIV-related and depressive symptoms (cognitive-affective and somatic) associated with QoL domains. The sample consisted of 1194 HIV-infected patients, recruited from 10 Portuguese hospitals. QoL data were collected using the WHOQOL-HIV-Bref questionnaire. Patients also completed the Beck Depression Inventory. Of the 1194 patients, 185 (15.5%) were over 50 years old. Middle-aged and older patients reported significantly lower QoL in the physical, independence and social relationships domains. Regarding the specific facets of QoL, middle-aged and older patients reported significantly lower scores in seven of the 29 specific facets of the WHOQOL-HIV-Bref and higher scores in one facet (financial resources). Overall, among middle-aged and older patients, higher education, being employed, a shorter time since HIV diagnosis, use of combination anti-retroviral therapy and fewer depressive symptoms were significantly associated with higher QoL ratings. Our findings suggest that both cognitive-affective and somatic depressive symptoms account for significant variability in QoL scores in middle-aged and older patients. Because an important feature of healthy ageing is maintaining QoL, these data may provide useful information for tailoring age-appropriate and effective interventions to improve the mental health and QoL of middle-aged and older patients living with HIV.