Signaling functions of reactive oxygen species.
Signaling functions of reactive oxygen species.
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DOI：
10.1021/bi9020378
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发表时间：
2010-02-09
期刊：
影响因子：
2.9
通讯作者：
Ursini, Fulvio
中科院分区：
文献类型：
--
作者：
Forman, Henry Jay;Maiorino, Matilde;Ursini, Fulvio
我们回顾了活性氧的信号，这是一个重要的生理过程。然而，在活性氧中，H2O2最能满足作为第二信使的要求。它的酶促生产和降解，以及硫醇被H2O2氧化的要求，为信号传递所需的时间和地点提供了特异性。热力学和动力学方面的考虑表明，在半胱氨酸可能的氧化状态中，磺酸衍生物或二硫化物的形成可能与信号传导中的硫醇氧化还原开关有关。在这项工作中，根据硫醇过氧化物酶中催化半胱氨酸或硒代半胱氨酸的氧化机制，讨论了H2O2氧化蛋白质硫醇所需的一般限制条件，以使其足够快，从而与信号传导相关。虽然硫醇和H2O2之间的非酶促反应在大多数情况下过于缓慢，与信号传导相关，但这些过氧化物酶催化硫醇氧化为氧化还原信号传导提供了一种潜在的机制。
We review signaling by reactive oxygen species, which is emerging as a major physiological process. However, among the reactive oxygen species, H2O2 best fulfills the requirements of being a second messenger. Its enzymatic production and degradation, along with the requirements for the oxidation of thiols by H2O2, provide the specificity for time and place that are required in signaling. Both thermodynamic and kinetic considerations suggest that among possible oxidation states of cysteine, formation of sulfenic acid derivatives or disulfides can be relevant as thiol redox switches in signaling. In this work, the general constraints that are required for protein thiol oxidation by H2O2 to be fast enough to be relevant for signaling are discussed in light of the mechanism of oxidation of the catalytic cysteine or selenocysteine in thiol peroxidases. While the nonenzymatic reaction between thiol and H2O2 is, in most cases, too slow to be relevant in signaling, the enzymatic catalysis of thiol oxidation by these peroxidases provides a potential mechanism for redox signaling.
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