Distinctive distribution of AIM1 polymorphism among major human populations with different skin color
Distinctive distribution of AIM1 polymorphism among major human populations with different skin color
复制标题
DOI：
10.1007/s100380200007
复制
发表时间：
2002-01-01
影响因子：
3.5
通讯作者：
Ishida, T
中科院分区：
文献类型：
--
作者：
Nakayama, K;Fukamachi, S;Ishida, T
人类肤色的遗传背景一直是人类遗传学的一个重要课题，但其分子基础仍不清楚。AIM-1蛋白基因（AIM 1）最近被发现与青鳉鱼的体色有关。在寻找控制人类肤色变异的基因时，我们研究了该基因的遗传多态性，发现了一种单核苷酸多态性，该多态性与主要人群的肤色明显相关。
The genetic background for human skin color has been a major topic in human genetics, however, its molecular basis is still unclear. The gene for the AIM-1 protein (AIM1) was recently found to be responsible for the body color of medaka fish. In the search for the genes controlling human skin color variations, we have investigated genetic polymorphisms of this gene, and we have found a single-nucleotide polymorphism that has clear association with major human populations in terms of skin color.