A growth arrest-specific (gas) gene codes for a membrane protein
A growth arrest-specific (gas) gene codes for a membrane protein
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DOI：
10.1128/mcb.10.6.2924-2930.1990
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发表时间：
1990-06
影响因子：
5.3
通讯作者：
G. Manfioletti;M. E. Ruaro;G. Sal;L. Philipson;C. Schneider
中科院分区：
文献类型：
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作者：
G. Manfioletti;M. E. Ruaro;G. Sal;L. Philipson;C. Schneider
一组生长抑制特异性（气体）基因的表达是负调控的血清最近已被确定。我们报告的详细分析，这些基因之一（气体3）。通过血清的存在和不存在的调节的动力学进行了研究，并且发现该基因在转录后水平被调节。从核苷酸序列推导出的编码蛋白显示出与线粒体氧化还原酶的一些相似性，并且体外翻译确定该蛋白产物是跨膜糖蛋白。
A set of growth arrest-specific (gas) genes whose expression is negatively regulated by serum has recently been identified. We report on the detailed analysis of one of these genes (gas3). The kinetics of regulation by the presence and absence of serum were investigated, and it was found that this gene is regulated at the post-transcriptional level. The encoded protein deduced from the nucleotide sequence showed some similarity to a mitochondrial oxyreductase, and in vitro translation established that the protein product is a transmembrane glycoprotein.