Exercise Training Attenuates Neuropathic Pain and Cytokine Expression After Chronic Constriction Injury of Rat Sciatic Nerve
Exercise Training Attenuates Neuropathic Pain and Cytokine Expression After Chronic Constriction Injury of Rat Sciatic Nerve
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DOI：
10.1213/ane.0b013e31824c4ed4
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发表时间：
2012-06-01
影响因子：
5.7
通讯作者：
Hung, Ching-Hsia
中科院分区：
文献类型：
--
作者：
Chen, Yu-Wen;Li, Yung-Tsung;Hung, Ching-Hsia
背景：运动治疗神经性疼痛的潜在机制尚不清楚。我们研究了体育锻炼是否调节坐骨神经慢性缩窄损伤（CCI）后的功能恢复和热休克蛋白 72（Hsp72）、肿瘤坏死因子-α（TNF-α）和白细胞介素 1 β（IL-1 β）的表达。方法：雄性 Sprague-Dawley 大鼠分为 7 组：对照组、假手术组（SO）、游泳组或游泳组。 跑步机锻炼（SOSE 或 SOTE）、CCI、CCI 游泳或跑步机锻炼（CCISE 或 CCITE）。记录体重、热撤退潜伏期、机械撤退阈值以及坐骨神经中Hsp72、TNF-α和IL-1β的表达。结果：对照组和SO组的体重较SOSE、SOTE、CCI、CCISE和CCITE组重。 CCI 后第 21 天，与未运动的 CCI 大鼠相比，进行游泳或跑步机运动的 CCI 大鼠的热缩回潜伏期和机械缩回阈值显着增加。 CCI 后第 21 天，CCISE 和 CCITE 组的坐骨神经中 Hsp72 表达更高，TNF-α 或 IL-1 β 水平低于 CCI 组。结论：这些结果表明，渐进式运动训练可减轻周围神经性疼痛以及 TNF-α 和 IL-1 β 的过度产生，并增加坐骨神经 CCI 后 HSP72 的表达。 神经。 （麻醉分析 2012；114：1330-7）
BACKGROUND: The underlying mechanism of exercise on neuropathic pain is not well understood. We investigated whether physical exercise regulates the functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor-alpha (TNF-alpha), and interlukin-1 beta (IL-1 beta) expression after chronic constriction injury (CCI) of the sciatic nerve.METHODS: Male Sprague-Dawley rats were divided into 7 groups: control, sham operated (SO), SO with swimming or treadmill exercise (SOSE or SOTE), CCI, CCI with swimming or treadmill exercise (CCISE or CCITE). We recorded body weight, thermal withdrawal latency, and mechanical withdrawal threshold as well as Hsp72, TNF-alpha, and IL-1 beta expression in sciatic nerve.RESULTS: The body weights in the control and SO groups were heavier than those in the SOSE, SOTE, CCI, CCISE, and CCITE groups. CCI rats with swimming or treadmill exercise showed significant increase in thermal withdrawal latency and mechanical withdrawal threshold when compared with CCI rats without exercise on day 21 after CCI. Both CCISE and CCITE groups demonstrated greater Hsp72 expression and lower TNF-alpha or IL-1 beta level than did the CCI group in sciatic nerve on day 21 after CCI.CONCLUSIONS: These results suggest that progressive exercise training decreases peripheral neuropathic pain as well as TNF-alpha and IL-1 beta overproduction and increases HSP72 expression after CCI of the sciatic nerve. (Anesth Analg 2012;114:1330-7)