TFIIH: A key component in multiple DNA transactions
TFIIH: A key component in multiple DNA transactions
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DOI：
10.1016/s0959-437x(96)90006-4
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发表时间：
1996-02-01
影响因子：
4
通讯作者：
Vermeulen, W
中科院分区：
文献类型：
--
作者：
Hoeijmakers, JHJ;Egly, JM;Vermeulen, W
转录因子 TFIIH 是一种多用途、多功能的蛋白质复合物，具有多种作用。除了在基础转录中的作用外，TFIIH 还与 DNA 修复和（可能）细胞周期控制（两者都是预防癌变所必需的）密切相关，并且在其他过程中也可能发挥作用。因此，这是有效地将一个组件用于多种用途的一个引人注目的例子。巧妙地将这一必需因子纳入重要但非必需的机制（例如 DNA 修复）中，可以预防癌症。 TFIIH 在转录功能中的关键作用使得 TFIIH 突变失活对细胞致命。如果没有这种转录连接，此类突变将导致遗传不稳定和肿瘤发生。
The transcription factor TFIIH is a versatile, multi-functional protein complex with multiple engagements. Apart from its role in basal transcription, TFIIH is intimately implicated in DNA repair and (probably) in cell cycle control (both of which are required to prevent carcinogenesis) as well as having possible roles in other processes. Thus, it is a striking example of the efficient use of one component for many purposes. Ingeniously, the incorporation of this essential factor into important, but non-essential, mechanisms, such as DNA repair, protects against cancer. The critical role of TFIIH in transcription function renders inactivating TFIIH mutations lethal to cells. Without this transcription connection, such mutations would lead to genetic instability and oncogenesis.