Pink1, the first ubiquitin kinase
Pink1, the first ubiquitin kinase
复制标题
Pink1，第一个泛素激酶
作者：
Xinde Zheng;T. Hunter
Pink1和Parkin通过遗传性早发性帕金森病的研究确定，参与线粒体质量控制。Parkin E3泛素连接酶活性被Pink1激酶活性激活，尽管其机制仍然是难以捉摸的。最近的三份报告揭示了一个令人惊讶的机制，其中Pink1直接磷酸化泛素以增强Parkin活性。
Pink1 and Parkin, identified through studies of hereditary early onset Parkinson's disease, are involved in mitochondria quality control. Parkin E3 ubiquitin ligase activity is activated by Pink1 kinase activity, although the mechanism is still elusive. Three recent reports uncover a surprising mechanism in which Pink1 directly phosphorylates ubiquitin to boost Parkin activity.
影响因子：
7.2
作者：
Narendra, Derek;Walker, John E.;Youle, Richard
通讯作者：
Youle, Richard