Pregnancy outcomes in women potentially exposed to occupational solvents and women working in the electronics industry.
Pregnancy outcomes in women potentially exposed to occupational solvents and women working in the electronics industry.
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可能接触职业溶剂的女性和电子行业工作女性的妊娠结局。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
S. Swan
中科院分区：
文献类型：
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作者：
Jane Lipscomb;L. Fenster;M. Wrensch;Dennis Shusterman;S. Swan
在一项针对1980年至1985年间加利福尼亚州1038名孕妇开展的大型社区横断面生殖健康研究中，对职业性溶剂暴露和/或电子生产工作与不良妊娠结局之间的关联进行了研究。职业性溶剂暴露通过两种不同的方法确定：由专家判定可能包括溶剂暴露的人口普查局编码以及自我报告的暴露情况。通过任一方法分类的孕早期溶剂暴露（n = 52）与自然流产显著相关，调整后的优势比为3.34（95%置信区间为1.42 - 7.81）。在29名报告经常且每日有溶剂暴露的女性中，调整后的优势比增加至4.44（95%置信区间为1.86 - 10.58）。电子装配工作与分娩低体重儿显著相关（调整后的优势比为5.38；95%置信区间为1.42 - 20.46），但与自然流产无关。需要使用生物监测和/或其他客观暴露测量方法进行进一步研究以验证这些发现。
Associations of occupational solvent exposure and/or work in electronics production with adverse pregnancy outcomes were examined in a large cross-sectional community-based reproductive health study of 1038 California women pregnant between 1980 and 1985. Occupational solvent exposure was determined by two different methods: Bureau of Census codes judged by experts to probably include solvent exposure and self-reported exposure. First trimester solvent exposure classified by either method (n = 52) was significantly associated with spontaneous abortion, adjusted odds ratio 3.34 (95% confidence interval 1.42, 7.81). Among 29 women reporting regular and daily solvent exposure, the adjusted odds ratio increased to 4.44 (95% confidence interval 1.86, 10.58). Work in electronics assembly was significantly associated with delivering a low birth weight infant (adjusted odds ratio 5.38; 95% confidence interval 1.42, 20.46) but was not associated with spontaneous abortions. Further research using biologic monitoring and/or other objective measures of exposure is needed to validate these findings.