RNA-mediated chromatin-based silencing in plants
RNA-mediated chromatin-based silencing in plants
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DOI：
10.1016/j.ceb.2009.01.025
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发表时间：
2009-06-01
影响因子：
7.5
通讯作者：
Matzke, Antonius J. M.
中科院分区：
文献类型：
--
作者：
Matzke, Marjori;Kanno, Tatsuo;Matzke, Antonius J. M.
植物已经进化出一种精细的转录机制，专门用于引发序列特异性的、基于染色质的基因沉默。两个与Pol ii相关的植物特异性RNA聚合酶，称为Pol IV和Pol V，与RNA干扰机制的蛋白质合作，产生参与表观遗传调控的长和短非编码RNA。正如各种遗传、分子和基因组技术所揭示的那样，这些rna在植物中广泛使用，指导其基因组中DNA胞嘧啶甲基化的建立、传播和去除。rna介导的染色质水平沉默越来越多地与发育、应激反应和自然表观遗传变异有关，这些变异可能促进表型多样性、生理可塑性和进化变化。
Plants have evolved an elaborate transcriptional machinery dedicated to eliciting sequence-specific, chromatin-based gene silencing. Two Pol II-related, plant-specific RNA polymerases, named Pol IV and Pol V, collaborate with proteins of the RNA interference machinery to generate long and short noncoding RNAs involved in epigenetic regulation. As revealed by a variety of genetic, molecular, and genomic technologies, these RNAs are used extensively in plants to direct the establishment, spread, and removal of DNA cytosine methylation throughout their genomes. RNA-mediated chromatin-level silencing is increasingly implicated in development, stress responses, and natural epigenetic variation that may promote phenotypic diversity, physiological plasticity, and evolutionary change.