Apolipoprotein E polymorphism and fertility:: a study in pre-industrial populations
Apolipoprotein E polymorphism and fertility:: a study in pre-industrial populations
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DOI：
10.1093/molehr/gah082
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发表时间：
2004-08-01
影响因子：
4
通讯作者：
De Stefano, GF
中科院分区：
文献类型：
--
作者：
Corbo, RM;Ulizzi, L;De Stefano, GF
人载脂蛋白E是类固醇激素生成组织中类固醇激素生成的胆固醇前体的最重要供应者，因此可以在类固醇激素功能的调节中发挥作用，并影响人类生殖。这一假说已被证实的研究描述了差异生育与共同的载脂蛋白（APOE）基因型在两个欧洲人群。在本调查中，APOE基因变异对生育力的影响进行了研究，在两个厄瓜多尔人口，非洲裔厄瓜多尔人（57名妇女）和卡亚帕印第安人（27名妇女）。此外，还调查了有关妇女生育率的一些生物人口变量（124名非洲裔厄瓜多尔妇女; 40名卡亚帕妇女），以更好地了解这些工业化前人口中的APOE与生育率的关系。这两个人口群体的总体生育率都很高（非洲裔厄瓜多尔人和卡亚帕人分别为6.5和6.2）。当仅考虑接近生育期结束的妇女（大于或等于40岁）时，两组之间观察到更显著的差异（9.1比7.7，P=0.09）。在这两个社区，最高数量的儿童被发现与e*4/e*3基因型; e*4/e*3基因型频率（0.50）在非洲裔厄瓜多尔妇女与9-17个孩子是约三倍的妇女与0-8个孩子（0.14）（P=0.02）。目前的研究结果与欧洲人群中观察到的结果不同，其中e*3/e*3是与最高生殖效率相关的基因型。这种不一致性的一个可能的解释可能是由于与e*3和e*4等位基因相关的不同功能特性以及基因型与环境因素（包括生殖策略）的相互作用。
Human apolipoprotein E is the most important supplier of the cholesterol precursor for steroid hormone production in steroidogenic tissues and therefore could play a role in the regulation of steroid hormone function and influence human reproduction. This hypothesis has been confirmed by studies describing a differential fertility associated with common apolipoprotein (APOE) genotypes in two European populations. In the present investigation the impact of APOE genetic variation on fertility was studied in two Ecuadorian populations, African-Ecuadorians (57 women) and Cayapa Indians (27 women). In addition some biodemographic variables concerning women's fertility were investigated (124 African-Ecuadorian women; 40 Cayapa women) to better understand the APOE-fertility relationships in these pre-industrial populations. General fertility rates in both populations were very high (6.5 and 6.2 for the African-Ecuadorians and for the Cayapa respectively). When considering only women near the end of reproductive life (greater than or equal to40 years), a more marked difference was observed between the two groups (9.1 versus 7.7, P=0.09). In both communities, the highest number of children was found to be associated with the e*4/e*3 genotype; the e*4/e*3 genotype frequency (0.50) in the African-Ecuadorian women with 9-17 children was about three times that of the women with 0-8 children (0.14) (P=0.02). The present findings are at variance with those observed in European populations, where e*3/e*3 was the genotype associated with the highest reproductive efficiency. A possible explanation for this inconsistency could be due to the different functional properties associated with the e*3 and e*4 alleles and to genotype interactions with environmental factors including reproductive strategies.