VisANT: an online visualization and analysis tool for biological interaction data.
VisANT: an online visualization and analysis tool for biological interaction data.
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DOI：
10.1186/1471-2105-5-17
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发表时间：
2004-02-19
影响因子：
3
通讯作者：
DeLisi C
中科院分区：
文献类型：
--
作者：
Hu Z;Mellor J;Wu J;DeLisi C
用于确定所有类型的生物分子--基因、蛋白质、非编码DNA、代谢物和小分子--之间关系的新技术，正在为广泛讨论的细胞事实爆炸做出重大贡献。这些技术产生的数据促进了细胞作为一个相互连接的信息网络的图像，分子组件在拓扑结构中相互连接，可以编码和代表细胞功能的许多特征。这种生物学的网络化观点为系统地理解活分子系统带来了潜力。我们提出了VisANT，一个应用程序集成到一个有凝聚力的，图形界面的生物分子相互作用的数据。该软件具有多层架构，可实现数据灵活性，将用于数据检索的后端模块与前端可视化和分析包分离。VisANT是一个供研究人员免费使用的开源工具，并为大量已发表的生物分子相互作用数据集提供在线界面，包括用户输入的数据集。该系统与标准数据库集成，用于组织注释，包括GenBank，KEGG和SwissProt。VisANT是一个基于Java的，平台无关的工具，适用于广泛的生物学应用，包括研究途径，基因调控和系统生物学。VisANT已开发用于提供生物相互作用数据集的交互式可视化挖掘。新软件提供了一个通用工具，用于在序列，途径，结构和相关注释的背景下挖掘和可视化这些数据。交互和预测关联数据可以使用各种内置功能进行组合、叠加、操作和分析。VisANT可在。
New techniques for determining relationships between biomolecules of all types – genes, proteins, noncoding DNA, metabolites and small molecules – are now making a substantial contribution to the widely discussed explosion of facts about the cell. The data generated by these techniques promote a picture of the cell as an interconnected information network, with molecular components linked with one another in topologies that can encode and represent many features of cellular function. This networked view of biology brings the potential for systematic understanding of living molecular systems. We present VisANT, an application for integrating biomolecular interaction data into a cohesive, graphical interface. This software features a multi-tiered architecture for data flexibility, separating back-end modules for data retrieval from a front-end visualization and analysis package. VisANT is a freely available, open-source tool for researchers, and offers an online interface for a large range of published data sets on biomolecular interactions, including those entered by users. This system is integrated with standard databases for organized annotation, including GenBank, KEGG and SwissProt. VisANT is a Java-based, platform-independent tool suitable for a wide range of biological applications, including studies of pathways, gene regulation and systems biology. VisANT has been developed to provide interactive visual mining of biological interaction data sets. The new software provides a general tool for mining and visualizing such data in the context of sequence, pathway, structure, and associated annotations. Interaction and predicted association data can be combined, overlaid, manipulated and analyzed using a variety of built-in functions. VisANT is available at .