Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population.
Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population.
复制标题
中国汉族人群Wnt信号通路基因遗传变异与心肌梗死易感性的关系
DOI：
10.18632/oncotarget.10401
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发表时间：
2016-08-16
期刊：
影响因子：
--
通讯作者：
Ma YT
中科院分区：
文献类型：
--
作者：
Tao J;Wang YT;Abudoukelimu M;Yang YN;Li XM;Xie X;Chen BD;Liu F;He CH;Li HY;Ma YT
大量研究表明Wnt通路参与心肌梗死（MI）的发生和发展;然而，关于Wnt通路基因多态性对MI易感性影响的研究却很少。我们研究了Wnt通路基因的遗传变异与MI风险之间的可能相关性。采用PCR-RFLP方法对465例MI患者和485例健康对照者进行SFRP 1基因rs7832767 C > T、CTNNB 1基因rs 2293303 C > T和WISP 1基因rs 16893344 C > T多态性分析。我们发现SFRP 1 rs7832767变异等位基因（T）与MI风险显著增加相关[TT vs. CC：调整后比值比（AOR）= 3.13，95% CI = 1.78-5.51; CT/TT vs. CC：AOR = 1.53，95% CI = 1.12-2.08; TT vs. CC/CT：AOR = 2.87，95% CI = 1.66-4.97）]。CTNNB 1 rs 2293303也与MI风险显著相关（CT与CC：AOR = 3.48，95% CI = 2.28-5.33; TT与CC：AOR = 7.37，95% CI = 2.08-26.16; CT/TT与CC：AOR = 3.72，95% CI = 2.46-5.62; TT与CC/CT：AOR = 5.52，95%CI = 1.58-19.28），WISP 1 rs 16893344多态性（CT与CC：AOR = 2.43，95% CI = 1.70-3.47; TT与CC：AOR = 5.17，95% CI = 1.85-14.41; CT/TT与CC：AOR = 2.58，95% CI = 1.83-3.66; TT与CC/CT：AOR = 3.88，95%CI = 1.41-10.64）。在按参与者的人口统计学和临床特征进行的分层分析中，这种关联仍然显着，只有少数例外。本研究首次证明Wnt通路基因多态性与中国汉族人群心肌梗死易感性相关。大样本流行病学研究和功能分析是必要的，以进一步验证我们的结果。
Numerous studies have implicated the Wnt pathway in the development and progression of myocardial infarction (MI); however, there are very few investigations addressing the effects of polymorphisms in the Wnt pathway genes on MI susceptibility. We investigated the possible correlation between genetic variations in Wnt pathway genes and MI risk. Three polymorphisms (rs7832767 C > T in SFRP1 gene, rs2293303 C > T in CTNNB1 gene, rs16893344 C > T in WISP1 gene) were finally selected and genotyped in 465 MI patients and 485 healthy controls, using the PCR-RFLP method. We found that the SFRP1 rs7832767 variant allele (T) was associated with a significantly increased risk of MI [TT vs. CC: adjusted odds ratio (AOR) = 3.13, 95% CI = 1.78-5.51; CT/TT vs. CC: AOR = 1.53, 95% CI = 1.12-2.08; TT vs. CC/CT: AOR = 2.87, 95% CI = 1.66-4.97)]. The significant association with MI risk was also found for the CTNNB1 rs2293303 (CT vs. CC: AOR = 3.48, 95% CI = 2.28-5.33; TT vs. CC: AOR = 7.37, 95% CI = 2.08-26.16; CT/TT vs. CC: AOR = 3.72, 95% CI = 2.46-5.62; TT vs. CC/CT: AOR = 5.52, 95% CI = 1.58-19.28), and WISP1 rs16893344 polymorphisms (CT vs. CC: AOR = 2.43, 95% CI = 1.70-3.47; TT vs. CC: AOR = 5.17, 95% CI = 1.85-14.41; CT/TT vs. CC: AOR = 2.58, 95% CI = 1.83-3.66; TT vs. CC/CT: AOR = 3.88, 95% CI = 1.41-10.64). The associations remain significant in stratified analysis by demographic and clinical characteristics of participants, with few exceptions. Our study provided the first evidence of the association between polymorphisms in the Wnt pathway genes and MI susceptibility in Chinese Han population. Epidemiological studies with larger samples and functional analyses are warranted to further verify our results.
影响因子：
3.7
作者：
Hu X;Shang M;Zhou J;Ye Y;Lu X;Tao C;Ying B;Wang L
通讯作者：
Wang L