PHOTOSENSITIZATION WITH BACTERIOCHLORINS
PHOTOSENSITIZATION WITH BACTERIOCHLORINS
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DOI：
10.1111/j.1751-1097.1993.tb09549.x
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发表时间：
1993-08-01
影响因子：
3.3
通讯作者：
HENDERSON, B
中科院分区：
文献类型：
--
作者：
KESSEL, D;SMITH, KM;HENDERSON, B
比较了一组细菌绿素的生物物理和光生物学性质与这些产品用于小鼠肿瘤的光动力疗法的功效。体内选择性光敏化的预测因素包括与脂蛋白的亲和力大于与白蛋白的亲和力、在照射波长下的消光系数和肿瘤/皮肤分布。疗效与不同敏化剂的循环血浆水平相关，但与细胞培养中的光动力治疗反应无关。
Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture.