Novel One-Pot Method for Chemoselective Bromination and Sequential Sonogashira Coupling
Novel One-Pot Method for Chemoselective Bromination and Sequential Sonogashira Coupling
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DOI：
10.1021/ol101110v
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发表时间：
2010-08-06
期刊：
影响因子：
5.2
通讯作者：
Saito, Takao
中科院分区：
文献类型：
--
作者：
Kutsumura, Noriki;Niwa, Kentaro;Saito, Takao
发展了一种烯丙醇衍生物溴化消除和Sonogashira偶联的一锅法。该方法的一个亮点是具有相邻O-官能团的邻位二溴烷烃的化学选择性DBU促进消除。
An efficient one-pot method for bromination-elimination of allyl alcohol derivatives and sequential Sonogashira coupling has been developed. A highlight of the method is chemoselective DBU-promoted elimination of vicinal dibromoalkanes having an adjacent O-functional group.