Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells
Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells
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DOI：
10.1254/jphs.sc0040209
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发表时间：
2005-05-01
影响因子：
3.5
通讯作者：
Nakaike, S
中科院分区：
文献类型：
--
作者：
Hashimoto, Y;Arai, I;Nakaike, S
研究了前列腺素D-2、PGE（2）和PGI（2）对小鼠瘙痒相关性抓挠反应和大鼠嗜碱性白血病细胞系RBL-2 H3组胺释放的影响。PGD（2）和酮替芬可抑制卵白蛋白致敏小鼠的抓挠反应，而PGE（2）和PGI（2）则无此作用。酮替芬也抑制化合物48/80诱导的抓挠，但不抑制PGD（2）、PGE（2）和PGI（2）。在体外，PGD（2）抑制抗原诱导的RBL-2 H3细胞组胺释放，而PGE（2）和PGI（2）则无此作用。这些发现表明PGD（2）通过抑制肥大细胞释放IgE介导的组胺来特异性抑制IgE介导的抓挠。
Effects of prostaglandin (PG) D-2, PGE(2), and PGI(2) on itch-associated scratching responses of mice and histamine release from the rat basophilic leukemia cell line RBL-2H3 were examined. PGD(2) and ketotifen but not PGE(2) and PGI(2) suppressed the scratching caused by ovalbumin injected into ovalbumin-sensitized mice. Ketotifen also suppressed compound 48/80-induced scratching but not PGD(2), PGE(2), and PGI(2). In vitro, PGD(2) suppressed the antigen-induced histamine release from RBL-2H3 cells, but PGE(2) and PGI(2) did not. These findings suggest that PGD(2) specificically suppressed IgE-mediated scratching by inhibiting IgE-mediated histamine release from mast cells.