The functional neuroanatomical correlates of response variability: evidence from a response inhibition task
The functional neuroanatomical correlates of response variability: evidence from a response inhibition task
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DOI：
10.1016/j.neuropsychologia.2004.05.007
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发表时间：
2004-01-01
期刊：
影响因子：
2.6
通讯作者：
Garavan, H
中科院分区：
文献类型：
--
作者：
Bellgrove, MA;Hester, R;Garavan, H
个体内表现变异性可能是执行控制过程实施效率的一个重要指标。病变研究表明，额叶损伤伴随着这种变异性的增加。在此，我们首次试图通过使用事件相关功能性磁共振成像（ER - fMRI）设计和“进行/不进行”反应抑制范式，研究在健康受试者中执行控制的功能性神经解剖结构是如何受到表现变异性调节的。行为结果显示，“进行”反应时间变异性的个体差异是抑制成功的一个强有力预测因素，并且平均“进行”反应时间的差异无法解释这种效应。与任务相关的大脑激活在一个由双侧额中回区域以及右侧顶下小叶和丘脑区域组成的分布式抑制网络内与个体内变异性呈正相关。行为数据和fMRI数据都与以下解释一致：那些个体内变异性相对较高的受试者更大程度地激活了抑制区域，这也许反映了该组对自上而下的执行控制有更大的需求，这一发现可能与执行/注意力控制障碍有关。（C）2004爱思唯尔有限公司。保留所有权利。
Intra-individual performance variability may be an important index of the efficiency with which executive control processes are implemented, Lesion studies suggest that damage to the frontal lobes is accompanied by an increase in such variability. Here we sought for the first time to investigate how the functional neuroanatomy of executive control is modulated by performance variability in healthy subjects by using an event-related functional magnetic resonance imaging (ER-fMRI) design and a Go/No-go response inhibition paradigm. Behavioural results revealed that individual differences in Go response time variability were a strong predictor of inhibitory success and that differences in mean Go response time could not account for this effect. Task-related brain activation was positively correlated with intra-individual variability within a distributed inhibitory network consisting of bilateral middle frontal areas and right inferior parietal and thalamic regions. Both the behavioural and fMRI data are consistent with the interpretation that those subjects with relatively higher intra-individual variability activate inhibitory regions to a greater extent, perhaps reflecting a greater requirement for top-down executive control in this group, a finding that may be relevant to disorders of executive/attentional control. (C) 2004 Elsevier Ltd. All rights reserved.