Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers
Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers
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DOI：
10.1093/brain/awq310
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发表时间：
2011-01-01
期刊：
影响因子：
14.5
通讯作者：
Rossor, Martin N.
中科院分区：
文献类型：
--
作者：
Knight, William D.;Okello, Aren A.;Rossor, Martin N.
（11）碳-匹兹堡化合物B正电子发射断层扫描研究表明，早老素1突变携带者的纹状体中存在早期和显著的淀粉样蛋白沉积。本横断面研究检查了7种早老素1突变的症状前和轻度受累（简易精神状态检查20）携带者的（11）碳-匹兹堡化合物B正电子发射断层扫描成像概况，并将其与对照组和有症状的散发性阿尔茨海默病病例进行比较。使用脑桥作为参考区域创建了代表（11）碳-匹兹堡化合物B保留60 - 90 min的参数比率图像，并研究了9个感兴趣区域。我们证实，增加的淀粉样蛋白负荷可检测到在症状前早老素1突变携带者与（11）碳匹兹堡化合物B正电子发射断层扫描和保留的模式是异质性的。早老素1和散发性阿尔茨海默病组的比较显示，早老素1组的丘脑保留显著更大，散发性阿尔茨海默病组的额颞保留显著更大。少数早老素1突变的个体显示小脑（11）碳-匹兹堡化合物B保留增加，表明该区域可能不适合作为家族性阿尔茨海默病的参考区域。
(11)Carbon-Pittsburgh compound B positron emission tomography studies have suggested early and prominent amyloid deposition in the striatum in presenilin 1 mutation carriers. This cross-sectional study examines the (11)Carbon-Pittsburgh compound B positron emission tomography imaging profiles of presymptomatic and mildly affected (mini-mental state examination epsilon 20) carriers of seven presenilin 1 mutations, comparing them with groups of controls and symptomatic sporadic Alzheimer's disease cases. Parametric ratio images representing (11)Carbon-Pittsburgh compound B retention from 60 to 90 min were created using the pons as a reference region and nine regions of interest were studied. We confirmed that increased amyloid load may be detected in presymptomatic presenilin 1 mutation carriers with (11)Carbon-Pittsburgh compound B positron emission tomography and that the pattern of retention is heterogeneous. Comparison of presenilin 1 and sporadic Alzheimer's disease groups revealed significantly greater thalamic retention in the presenilin 1 group and significantly greater frontotemporal retention in the sporadic Alzheimer's disease group. A few individuals with presenilin 1 mutations showed increased cerebellar (11)Carbon-Pittsburgh compound B retention suggesting that this region may not be as suitable a reference region in familial Alzheimer's disease.