Sex differences in susceptibility to viral infection of the central nervous system
Sex differences in susceptibility to viral infection of the central nervous system
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DOI：
10.1016/s0165-5728(96)00022-7
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发表时间：
1996-06-01
影响因子：
3.3
通讯作者：
Reiss, CS
中科院分区：
文献类型：
--
作者：
Barna, M;Komatsu, T;Reiss, CS
我们已经描述了雄性和雌性 BALB/c 和 BALB/c-H-2(dm2) (dm2) 小鼠在中枢神经系统 (CNS) 实验性嗜神经病毒感染中恢复的显着差异。鼻内接种水泡性口炎病毒（VSV）后，对雌性小鼠的组织匀浆进行分析，发现病毒滴度较低。雌性小鼠大脑从头端到尾端的病毒传播也显着减少。两种品系的雌性小鼠对这种病毒损伤的反应增强，与一氧化氮合酶（NOS）I、II和III型表达水平的增加、反应性星形胶质细胞患病率的增加、星形胶质细胞、内皮细胞和小胶质细胞上主要组织相容性复合体（MHC）II类分子的早期表达和增强水平以及星形胶质细胞中T细胞浸润的增加相关。 雌性 BALB/c 小鼠。总而言之，这些发现记录了中枢神经系统免疫中的性别二态性，并可能提供对许多性别偏见疾病背后的一些机制的理解。
We have characterized striking differences in recovery of male and female BALB/c and BALB/c-H-2(dm2) (dm2) mice from an experimental neurotropic viral infection of the central nervous system (CNS). Following intranasal inoculation of vesicular stomatitis virus (VSV), assays of tissue homogenates from female mice produced lower viral titers. There was also a significant reduction in the spread of virus from the rostral to caudal end of the brain in female mice. Enhanced recovery by female mice of both strains in response to this viral insult correlates with increased levels of Nitric Oxide Synthase (NOS) types I, II, and III expression, an increased prevalence of reactive astrocytes, earlier and enhanced levels of expression of Major Histocompatabilty Complex (MHC) class II molecules on astrocytes, endothelial and microglial cells, and increased T cell infiltration in the female BALB/c mouse. Taken together, these findings document sexual dimorphism in CNS immunity, and may provide an understanding of some of the mechanisms underlying many sex-biased diseases.