Enzyme Immunoassay (EIA)/Enzyme-Linked Immunosorbent Assay (ELISA)
Enzyme Immunoassay (EIA)/Enzyme-Linked Immunosorbent Assay (ELISA)
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DOI：
10.1373/clinchem.2005.051532
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发表时间：
2005-12-01
影响因子：
9.3
通讯作者：
Lequin, RM
中科院分区：
文献类型：
--
作者：
Lequin, RM
本简要说明阐述了酶免疫测定（EIA）和酶联免疫吸附测定（ELISA）发明的历史背景。这些检测方法由瑞典斯德哥尔摩大学的Peter Perlmann和伊娃恩瓦尔研究小组以及荷兰的Anton Schuurs和Bauke货车Weemen研究小组同时独立开发。今天，全世界医学实验室的全自动仪器都使用免疫测定原理，以酶作为报告标记，对患者样本中的无数分析物进行常规测量。EIA/ELISA的影响反映在自20世纪70年代以来它作为关键词出现在文献中的绝大多数次数上。临床医生和他们的病人，医学实验室，体外诊断制造商，以及世界各地的医疗保健系统都要归功于这四位发明家。(c)2005年美国临床化学协会。
This brief note addresses the historical background of the invention of the enzyme immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA). These assays were developed independently and simultaneously by the research group of Peter Perlmann and Eva Engvall at Stockholm University in Sweden and by the research group of Anton Schuurs and Bauke Van Weemen in The Netherlands. Today, fully automated instruments in medical laboratories around the world use the immunoassay principle with an enzyme as the reporter label for routine measurements of innumerable analytes in patient samples. The impact of EIA/ELISA is reflected in the overwhelmingly large number of times it has appeared as a keyword in the literature since the 1970s. Clinicians and their patients, medical laboratories in vitro diagnostics manufacturers, and worldwide healthcare systems owe much to these four inventors. (c) 2005 American Association for Clinical Chemistry.