Psychedelics and the essential importance of context
Psychedelics and the essential importance of context
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DOI：
10.1177/0269881118754710
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发表时间：
2018-07-01
影响因子：
4.1
通讯作者：
Kaelen, Mendel
中科院分区：
文献类型：
--
作者：
Carhart-Harris, Robin L.;Roseman, Leor;Kaelen, Mendel
随着现代试验支持迷幻药的治疗潜力，以及各种媒体继续激起公众兴趣，迷幻药正在掀起波澜。在这篇评论文章中，我们提请注意迷幻治疗模型的一个长期公认的组成部分，即“设置”和“设置”-在这里被归入“上下文”一词。我们强调：（a）传统致幻剂的药理机制（5-HT 2A受体激动作用和相关的可塑性），我们认为这使它们的作用对环境特别敏感，（B）用于测试关于迷幻剂和环境之间的积极相互作用的假设的研究设计，以及（c）我们小组关于迷幻体验质量的背景决定因素以及急性体验如何预测随后的长期-长期心理健康结果。我们希望这篇文章可以：（a）提供迷幻药研究的良好实践，（B）提供优化治疗模式的路线图，（c）帮助解决仍然围绕这些化合物的无益的污名，同时为长期持有的关于迷幻药使用背景的至关重要性的假设建立证据基础，这有助于最大限度地减少危害并最大限度地提高潜在利益。
Psychedelic drugs are making waves as modern trials support their therapeutic potential and various media continue to pique public interest. In this opinion piece, we draw attention to a long-recognised component of the psychedelic treatment model, namely 'set' and 'setting' - subsumed here under the umbrella term 'context'. We highlight: (a) the pharmacological mechanisms of classic psychedelics (5-HT2A receptor agonism and associated plasticity) that we believe render their effects exceptionally sensitive to context, (b) a study design for testing assumptions regarding positive interactions between psychedelics and context, and (c) new findings from our group regarding contextual determinants of the quality of a psychedelic experience and how acute experience predicts subsequent long-term mental health outcomes. We hope that this article can: (a) inform on good practice in psychedelic research, (b) provide a roadmap for optimising treatment models, and (c) help tackle unhelpful stigma still surrounding these compounds, while developing an evidence base for long-held assumptions about the critical importance of context in relation to psychedelic use that can help minimise harms and maximise potential benefits.