Pax6 controls progenitor cell identity and neuronal fate in response to graded shh signaling
Pax6 controls progenitor cell identity and neuronal fate in response to graded shh signaling
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DOI：
10.1016/s0092-8674(00)80323-2
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发表时间：
1997-07-11
期刊：
影响因子：
64.5
通讯作者：
Briscoe, J
中科院分区：
文献类型：
--
作者：
Ericson, J;Rashbass, P;Briscoe, J
运动神经元和腹膜间神经元的不同类别是由声音刺猬（SHH）的分级信号活性产生的。 SHH通过在腹侧神经管中建立不同的祖细胞群来控制神经元的命运，这些祖细胞群是由PAX6和NKX2.2的表达定义的。 PAX6建立了不同的腹侧祖细胞群体，并控制运动神经元和腹膜中间神经元的身份，从而介导腹侧脊髓和后脑的分级SHH信号传导。
Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.