Do sex hormones influence emotional modulation of pain and nociception in healthy women?
Do sex hormones influence emotional modulation of pain and nociception in healthy women?
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DOI：
10.1016/j.biopsycho.2013.10.003
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发表时间：
2013-12-01
影响因子：
2.6
通讯作者：
Terry, Ellen L.
中科院分区：
文献类型：
--
作者：
Rhudy, Jamie L.;Bartley, Emily J.;Terry, Ellen L.
性激素可能通过影响疼痛和伤害感受的情绪调节而导致个体间和个体内的疼痛差异。为了研究这一点，一个经过验证的图片观看范例被用来评估疼痛的情绪调节和伤害性屈曲反射（NFR;生理措施的伤害性感受）在卵泡中期，排卵，和黄体后期的健康正常周期的妇女（n = 40）的月经周期。唾液雌二醇，孕酮和睾酮在每个测试阶段进行了评估。疼痛/NFR的情绪调节在月经期没有差异，但低雌二醇与NFR的情绪调节（在所有阶段）和疼痛的情绪调节（排卵期和黄体晚期）较弱相关。有证据表明，未能情绪调节疼痛可能是慢性疼痛的危险因素，低雌二醇可能通过这种机制促进慢性疼痛。然而，未来的研究需要将这些发现扩展到疼痛，情绪和/或性激素紊乱的女性。(C)2013爱思唯尔有限公司版权所有。
Sex hormones may contribute to inter- and intra-individual differences in pain by influencing emotional modulation of pain and nociception. To study this, a well-validated picture-viewing paradigm was used to assess emotional modulation of pain and the nociceptive flexion reflex (NFR; physiologic measure of nociception) during mid-follicular, ovulatory, and late-luteal phases of the menstrual cycle in healthy normally cycling women (n = 40). Salivary estradiol, progesterone, and testosterone were assessed at each testing session. Emotional modulation of pain/NFR did not differ across menstrual phases, but low estradiol was associated with weaker emotional modulation of NFR (during all phases) and emotional modulation of pain (ovulatory and late-luteal phases). Given evidence that a failure to emotionally modulate pain might be a risk factor for chronic pain, low estradiol may promote chronic pain via this mechanism. However, future research is needed to extend these findings to women with disturbances of pain, emotion, and/or sex hormones. (C) 2013 Elsevier B.V. All rights reserved.