Distribution pattern of 68Ga-DOTATATE in disease-free patients
Distribution pattern of 68Ga-DOTATATE in disease-free patients
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DOI：
10.1097/mnm.0b013e32833f635e
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发表时间：
2010-12-01
影响因子：
1.5
通讯作者：
Bomanji, Jamshed B.
中科院分区：
文献类型：
--
作者：
Shastry, Manu;Kayani, Irfan;Bomanji, Jamshed B.
目的 Ga-68-DOTA-DPhe(1),Tyr(3)-octreotate (Ga-68 DOTATATE) 是一种生长抑素类似物，对生长抑素受体亚型 2 (sst(2)) 显示出高亲和力，已用于神经内分泌肿瘤成像。 然而，这种高灵敏度放射性示踪剂尚未描述正常摄取模式和潜在缺陷。因此，本研究的目的是概述生长抑素受体亚型 2 (sst(2)) 的正态分布模式。无病患者中的 Ga-68 DOTATATE，提供各个器官的标准化摄取值 (SUV)，并将我们的结果与体外 sst(2) 受体表达的当前知识进行比较方法 对 42 名患者（15 名男性和 27 名女性）进行 Ga-68-DOTATATE PET/计算机断层扫描 静脉注射约 145 MBq 示踪剂，并使用 GE Discovery ST PET/计算机断层扫描 SUV 进行成像结果 68Ga-DOTATATE 在表达 sst(2) 的器官（如垂体、甲状腺、胃壁、脾脏、肾上腺、肾脏、胰腺和前列腺）以及肝脏和唾液腺中被注意到，并在肠道、肾脏和膀胱的盆腔系统中具有排泄活性。SUV 范围为 0 1 至所考虑的器官中的 488 确定了解释甲状腺、胰腺淋巴结和肠道等器官中 Ga-68-DOTATATE 摄取的潜在陷阱结论这项研究显示 68Ga-DOTATATE 的分布模式概述了无病患者各种器官的 SUV 范围，并确定了成像过程中遇到的一些潜在陷阱 Nucl Med Commun 31 1025-1032 (C) 2010 Wolters Kluwer Health 竖条 Lippincott Williams & Wilkins 核医学通讯 2010 31 1025-1032
Purpose Ga-68-DOTA-DPhe(1),Tyr(3)-octreotate (Ga-68 DOTATATE) is a somatostatin analogue that shows high affinity for somatostatin receptor subtype 2 (sst(2)) and has been used for imaging neuroendocrine tumours However, normal uptake patterns and potential pitfalls have not been described with this high-sensitivity radiotracer The aim of this study was therefore to outline the normal distribution pattern of Ga-68 DOTATATE in disease-free patients, to provide standardized uptake values (SUVs) of various organs and to compare our results with the current knowledge on sst(2) receptor expression in vitroMethods Ga-68-DOTATATE PET/computed tomography was performed in 42 patients (15 men and 27 women) Approximately 145 MBq of tracer was injected intravenously and imaging was performed using a GE Discovery ST PET/computed tomography scanner SUVs were calculated on the reconstructed images for various organsResults 68Ga-DOTATATE uptake was noted in the sst(2)-expressing organs such as pituitary, thyroid, stomach wall, spleen, adrenals, kidneys, pancreas and prostate and in the liver and salivary glands, with excreted activity in the bowel and in the pelvicalyceal system of the kidneys and urinary bladder The SUVs ranged from 0 1 to 488 in the organs considered Potential pitfalls in interpreting the Ga-68-DOTATATE uptake in organs such as thyroid, pancreas lymph nodes and bowel were identifiedConclusion This study shows the distribution pattern of 68Ga-DOTATATE outlines the range of SUVs for various organs in disease-free patients and identifies some of the potential pitfalls encountered during imaging Nucl Med Commun 31 1025-1032 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins Nuclear Medicine Communications 2010 31 1025-1032