3D Printing of Biocompatible Supramolecular Polymers and their Composites
3D Printing of Biocompatible Supramolecular Polymers and their Composites
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DOI：
10.1021/acsami.5b10471
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发表时间：
2016-02-10
影响因子：
9.5
通讯作者：
Hayes, Wayne
中科院分区：
文献类型：
--
作者：
Hart, Lewis R.;Li, Siwei;Hayes, Wayne
一系列能够通过超分子相互作用自组装成无限网络的聚合物已被设计，合成和表征用于3D打印应用。生物相容性聚合物及其与二氧化硅纳米颗粒的复合材料被成功地用于存款简单的立方结构以及更复杂的扭曲金字塔特征。根据ISO 10993-5和10993-12标准茶，发现聚合物对软骨形成细胞系没有毒性，并且细胞附着在超分子聚合物上，如通过共聚焦显微镜所证明的。然后将二氧化硅纳米颗粒分散在聚合物基质中，得到一种复合材料，该材料针对喷墨打印进行了优化。混合材料在初步测试中显示出促进更复杂结构的3D沉积的前景。
A series of polymers capable of self-assembling into infinite networks via supramolecular interactions have been designed, synthesized, and characterized for use in 3D printing applications. The biocompatible polymers and their composites with silica nanoparticles were successfully utilized to deposit both simple cubic structures, as well as a more complex twisted pyramidal feature. The polymers were found to be not toxic to a chondrogenic cell line, according to ISO 10993-5 and 10993-12 standard teas and the cells attached to the supramolecular polymers as demonstrated by confocal microscopy. Silica nanoparticles were then dispersed within the polymer matrix, yielding a composite material which was optimized for inkjet printing. The hybrid material showed promise in preliminary tests to facilitate the 3D deposition of a more complex structure.