Dose-specific effects of alcohol on the lifespan of mice and the possible relevance to man.
Dose-specific effects of alcohol on the lifespan of mice and the possible relevance to man.
复制标题
酒精对小鼠寿命的剂量特异性影响及其与人类的可能相关性。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
Y. Israel
中科院分区：
文献类型：
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作者：
W. Schmidt;R. Popham;Y. Israel
总结
为了确定成年期间每日饮酒对寿命的影响，将三组雄性小鼠（C57BL/J0J品系）（C57BL/J0J品系）分成三组，将其中一只关在笼子里，分别给予3.5%、7.5%和J2% v/v的蒸馏水酒精作为唯一的饮水来源。根据相对代谢能力，由此产生的消耗水平可以被认为与人类中度至酒精摄入量的范围相当。两个对照组，每组 100 只小鼠，一组单独圈养，另一组将 5 只小鼠圈养在一个笼子里，随意饮用蒸馏水。低度酒精和单独饲养的饮水对照组的生存曲线没有差异。五组中，中度酒精小鼠的平均寿命最长，而高度酒精小鼠的平均寿命最短。尽管高酒精组的早期死亡表明肝脏异常率较高，但在死后组织学中没有明显的与酒精相关的组间差异。讨论了研究结果对人类的适用性。
Summary
To determine the effects on lifespan of daily consumption of alcohol throughout adulthood, three groups of 100 male mice each (strain C57BL/J0J)-housed one to a cage-were given 3.5%, 7.5% and J2% v/v alcohol in distilled water as the only source of drinking fluid. On the basis of relative metabolic capacity, the resulting consumption levels could be considered comparable to a range in man from a moderate to an alcoholic intake. Two control groups of 100 mice each-one group singly housed and the other housed five to a cage-received distilled water ad libitum. There was no difference between the survival curves of the low alcohol and water-drinking singly housed controls. The medium alcohol mice had the longest mean lifespan of the five groups and the high alcohol mice had the shortest. There were no clear alcohol-related group differences in post mortem histology, although the early deaths in the high alcohol group showed evidence of a high rate of liver abnormality. The applicability of the findings to man is discussed.