DECLINE IN THE RISK OF MYOCARDIAL-INFARCTION AMONG WOMEN WHO STOP SMOKING
DECLINE IN THE RISK OF MYOCARDIAL-INFARCTION AMONG WOMEN WHO STOP SMOKING
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DOI：
10.1056/nejm199001253220401
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发表时间：
1990-01-25
影响因子：
158.5
通讯作者：
SHAPIRO, S
中科院分区：
文献类型：
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作者：
ROSENBERG, L;PALMER, JR;SHAPIRO, S
为了评估戒烟与女性首次心肌梗死风险的关系，我们在一项以医院为基础的病例对照研究中，对910例首次心肌梗死患者的吸烟习惯与2375例对照组进行了比较，研究对象为25至64岁的女性。与从未吸烟的女性相比，目前吸烟者的相对风险估计为3.6（95%置信区间为3.0至4.4）。在总体戒烟者中，相应的相对风险估计值为1.2（95%置信区间为1.0至1.7）。在戒烟者中，戒烟不到两年的女性的相对风险估计值显着升高（相对风险为2.6; 95%置信区间为1.8至3.8）。大部分增加的风险在两到三年前戒烟的妇女中已经消失，三年或三年以上不吸烟的妇女的相对风险估计与从不吸烟的妇女几乎没有区别。无论吸烟量、吸烟持续时间、女性年龄或其他诱发因素的存在如何，同样的下降模式都很明显。这些数据表明，在女性中，与男性一样，吸烟者中首次心肌梗死风险的增加在戒烟后很快下降，并在两三年后基本消失。
To assess the relation of smoking cessation to the risk of a first myocardial infarction in women, we compared the smoking habits of 910 patients who had had their first myocardial infarction with those of 2375 controls in a hospital-based case-control study of women from 25 to 64 years of age. The estimate of relative risk among current smokers as compared with women who had never smoked was 3.6 (95 percent confidence interval, 3.0 to 4.4). Among exsmokers overall, the corresponding estimate of relative risk was 1.2 (95 percent confidence interval, 1.0 to 1.7). Among exsmokers, the estimate of relative risk was significantly elevated among women who had stopped smoking less than two years previously (relative risk, 2.6; 95 percent confidence interval, 1.8 to 3.8). Most of the increase in the risk had dissipated among the women who had stopped smoking two to three years previously, and the estimate of relative risk among the women had had not smoked for three or more years was virtually indistinguishable from theat among the women who had never smoked. The same pattern of decline was apparent regardless of the amount smoked, the duration of smoking, the age of the women, or the presence of other predisposing factors. These data suggest that in women, as in men, the increase in the risk of a first myocardial infarction among cigarette smokers declines soon after the cessation of smoking and is largely dissipated after two or three years.