Patient Profiling in Cartilage Regeneration Prognostic Factors Determining Success of Treatment for Cartilage Defects
Patient Profiling in Cartilage Regeneration Prognostic Factors Determining Success of Treatment for Cartilage Defects
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DOI：
10.1177/0363546509349765
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发表时间：
2009-11-01
影响因子：
4.8
通讯作者：
Saris, Daniel B. F.
中科院分区：
文献类型：
--
作者：
de Windt, Tommy S.;Bekkers, Joris E. J.;Saris, Daniel B. F.
Background: Cartilage therapy for focal articular lesions has been implemented for more than a decade, and it is becoming increasingly available. What is still lacking, however, is analysis of patient characteristics to help improve outcome or select patients for specific treatment.Purpose: To analyze the prognostic value of patient age and defect size, age, and location on clinical outcome 3 years after cartilage therapy.Study Design: Cohort study; Level of evidence, 3.Methods: Fifty-five patients (age, 35 9 years) were randomly selected from a prospective database. Each had a traumatic knee injury, each was treated for a focal cartilage lesion, and each was assessed with the Knee injury and Osteoarthritis Outcome Score (KOOS) 3 years after surgery. Patient characteristics (ie, patient age and defect size, age, and location) were tested for valid inclusion in the regression model. Multiple linear regression was used to determine which variables influenced clinical improvement. Binary KOOS scores were generated on the basis of age-matched healthy patients and assessed in a logistic regression analysis.Results: Normality tests confirmed normal distribution for each variable (P < .05). Defect size did not influence clinical improvement (P > .05). Clinical outcome regarding the treatment of medial defects was better than that of the lateral defects (10.38-25.26 points for the different KOOS subscales; P < .05). The KOOS improvement from baseline was better for patients = 30 years (7.31-29.24 points for the different KOOS subscales; P < .05). Patients with defects
