Applications of cell-penetrating peptides for tumor targeting and future cancer therapies.
Applications of cell-penetrating peptides for tumor targeting and future cancer therapies.
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DOI：
10.3390/ph5090991
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发表时间：
2012-09-12
期刊：
影响因子：
--
通讯作者：
Langel U
中科院分区：
文献类型：
--
作者：
Regberg J;Srimanee A;Langel U
细胞穿透肽为细胞内药物递送提供了非常有前途的策略。细胞穿透肽的一个相关临床应用是癌症治疗。基于肽的递送可以增加药物在肿瘤细胞中的摄取，从而增加常规小分子药物或基于寡核苷酸的治疗剂的治疗功效。本文综述了细胞穿透肽作为递送系统在癌症中的应用，讨论了药物装载、货物和递送的不同方面，以及靶向递送、可活化的细胞穿透肽和与细胞穿透肽偶联的可转导试剂的方法。
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides.